Ginkgolide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514468, 544153, 544378, 546174, 546197, 5462841, 5482678, 548526, 549297, A61K 31365, A61K 31535, C07D51900

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active

055411835

ABSTRACT:
The present invention is directed to new ginkgolide derivatives, which may be used for the prevention or treatment of various PAF-induced diseases, and the pharmaceutical uses of these derivatives. The present invention is also directed to a process for preparing these ginkgolide derivatives. ##STR1##

REFERENCES:
E. Sybertz, et al., "Cardiac, Coronary and Peripheral Vascular Effects of Acetyl Glyceryl Ether Phosphoryl Choline in the Anesthetized Dog," The Journal of Pharmacology and Experimental Therapeutics, vol. 232, No. 1, Jan., 1985, pp. 156-162.
G. Camussi, "Potential Roll of Platelet-Activating Factor in Renal Pathophysiology," Kidney International, vol. 29, No. 2, Feb., 1986, pp. 469-477.
P. Bessin, "PAF-Acether and Leukotriene Participation in Acute Circulatory Shock," Pharmacological Research Communications, vol. 18 Supplement, Aug., 1986, pp. 139-150.
G. Plante, et al., "Hemodynamic Effects of PAF-Acether," Pharmacological Research Communications, vol. 18 Supplement, Aug., 1986, pp. 173-179.
J. Benveniste, et al., "A Role for PAF-Acether (Platelet-Activating Factor) in Platelet-Dependent Vascular Diseases?," Circulation, vol. 72, No. 4, Oct., 1985, pp. 713-717.
T. Kamitani, et al., "Mechanisms(s) of the Hypotensive Effect of Synthetic 1-O-Octadecyl-2-O-Acetyl-Glycero-3-Phosphorylcholine," European Journal of Pharmacology, vol. 98, Nos. 3/4, (Mar. 1984) pp. 357-366.
G. Feuerstein, et al., "Prostaglandins, Leukotrienes, and Platelet-Activating Factor in Shock," Annual Review of Pharmacology and Toxicology, vol. 27, 1987, pp. 301-313.
M. L. Foegh, et al., "Prolongation of Cardiac Allograft Survival with BN 52021, a Specific Antagonist of Platelet-Activating Factor," Transplantation, vol. 42, No. 1, Jul., 1986, pp. 86-88.
R. Joseph, et al., "Sensitivity to PAF is Increased in Migraine Patients," Thrombosis and Haemostasis, vol. 57, No. 1, Feb. 1987, p. 125.
P. Barnes, et al., "PAF Closely Mimics Pathology of Asthma," Trends in Pharmacological Sciences, vol. 8, Aug. 1987, pp. 285-286.
K. F. Chung, et al., "PAF Antagonists: Their Potential Therapeutic Role in Asthma," Drugs, vol. 35, No. 2, Feb., 1988, pp. 93-103.
A. J. Lewis, et al., "The Effects of Antiallergic and Bronchodilator Drugs on Platelet-Activating Factor (PAF-Acether) Induced Bronchospasm and Platelet Aggregation," Agents and Actions, vol. 15, No. 5/6, Dec., 1984, pp. 636-642.
C. P. Page, et al., "Inflammatory Medicators of Asthma," European Journal of Respiratory Diseases, Supplement No. 144, vol. 68, 1986, pp. 163-189.
T. Nakamura, et al., "Platelet-Activating Factor in Late Asthmatic Response," International Archives of Allergy and Applied Immunology, vol. 82, 1987, pp. 57-61.
M. Sonnenblick, et al., "Body Positional Effect on Gas Exchange in Unilateral Pleural Effusion," Chest, vol. 83, No. 5, May, 1983, p. 784-786.
J. Bonnet, et al., "Dependency of the PAF-Acether Induced Bronchospasm on the Lipoxygenase Pathway in the Guinea-pig," Prostaglandins, vol. 26, No. 3, Sep., 1983, pp. 457-466.
T. Panetta, et al., "Effects of a Platelet Activating Factor Antagonist (BN 52021) on Free Fatty Acids, Diacylglycerols, Polyphosphoinositides and Blood Flow in the Gerbil Brain: Inhibition of Ischemia-Reperfusion Induced Cerebral Injury," Biochemical and Biophysical Research Communications, vol. 149, No. 2, Dec., 1987, pp. 580-587.
N. Bazan, "Arachidonic Acid in the Modulation of Excitable Membrane Function and at the Onset of Brain Damage," Arachidonic Acid Metabolism in the Nervous System, vol. 559, Jul. 1989, pp. 1-16.
P. Braquet, et al., "Perspectives in Platelet-Activating Factor Research," Pharmacological Reviews, vol. 39, No. 2, Jun., 1987, pp. 97-145.
A. Rosam, et al., "Potent Ulcerogenic Actions of Platelet-Activating Factor on the Stomach," Nature, vol. 319, No. 6048, Jan., 1986, pp. 54-56.
A. Lefer, et al., "Pathophysiological Mechanisms of Sudden Death Induced by Platelet Activating Factor," British Journal of Pharmacology, vol. 83, No. 1, Sep., 1984, pp. 125-130.
A. Myers, et al., "Glucocorticoid Protection Against PAF-Acether Toxicity in Mice," British Journal of Pharmacology, vol. 79, No. 2, Jun., 1983, pp. 595-598.
M. Criscuoli, et al., "PAF-Acether-Induced Death in Mice: Involvement of Arachidonate Metabolites and .beta.-Adrenoceptors," British Journal of Pharmacology, vol. 90, No. 1, Jan., 1987, pp. 203-209.
J. Young, et al., "Pharmacological Investigation of the Mechanisms of Platelet-Activating Factor Induced Mortality in the Mouse," Prostaglandins, vol. 30, No. 4, Oct., 1985, pp. 545-551.
P. Braquet, et al., "Platelet-Activating Factor and Cellular Immune Responses," Immunology Today, vol. 8, No. 11, 1987, pp. 345-352.
C. Caramelo, et al., "Increased Levels of Platelet-Activating Factor in Blood from Patients with Cirrhosis of the Liver," European Journal of Clinical Investigation, vol. 17, No. 1, Feb., 1987, pp. 7-11.
H. L. Spiegelberg, "Immunoglobins," Imflammation: Basic Principles and Clinical Correlates, Ch. 2 (1988), pp. 11-19.
A. Denjean, et al., "Bronchoconstriction Induced by Intratracheal Administration of Platelet-Activating Factor (PAF-Acether) in Baboons," Agents and Actions, vol. 11, Nos. 6/7, Dec. 1981, pp. 567-568.
N. Bazan, et al., "Platelet-Activating Factor and Polyunsaturated Fatty Acids in Cerebral Ischemia or Convulsions: Intracellular PAF-Binding Sites and Activation of a Fos/Jun./Ap-1 Transcriptional Signalling System," Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, vol. 26, No. 12 (1991), pp. 1236-1242.
G. Feuerstein, et al., "Effect of PAF on the Cardiovascular System," Platelet-Activating Factor and Related Lipid Mediators, Chap. 18, (1987) pp. 403-424.
F. Cuss, et al., "Effects of Inhaled Platelet Activating Factor on Pulmonary Function and Bronchial Responsiveness inf Man," The Lancet, vol. 13, No. 2 (1988), pp. 137-152.
D. Handley, "Development and Therapeutic Indications for PAF Receptor and Antagonists," Drugs of the Future, vol. 13, No. 2 (1988), pp. 137-152.

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