Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1999-05-28
2000-11-28
Stucker, Jeffrey
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241411, 4242691, A61K 39395, A61K 39002, A61K 39005, A61K 39008
Patent
active
06153191&
ABSTRACT:
The invention provides vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of preparing and methods of use of novel toxins, antibodies, vaccine strains and compositions that result from or are used in these methods.
REFERENCES:
patent: 4238478 (1980-12-01), Stojkovic
patent: 4314992 (1982-02-01), Bitakaramire
patent: 4404186 (1983-09-01), Ron
patent: 4493825 (1985-01-01), Platt
patent: 4639372 (1987-01-01), Murray
patent: 4687666 (1987-08-01), O'Daly
patent: 4724145 (1988-02-01), Murray
patent: 4808404 (1989-02-01), Bhogal
patent: 4837016 (1989-06-01), Holder
patent: 5028694 (1991-07-01), Mewman
patent: 5045313 (1991-09-01), Frenkel
patent: 5077044 (1991-12-01), Stocker
patent: 5106618 (1992-04-01), Beck
Edson et al.; An 88,000M Giardia Lamblia . . . ; Inf. and Immun.; vol. 54, No. 3; pp. 621-625, Dec. 1986.
Adam, The biology of Giardia spp., Microbiology Rev., 55 (4): 706-732 (1991).
Belosevic, et al., Observations on natural and experimental infections with giardia isolated from cats, Can J. Comp. Med., 48: 241-244 (1984).
Bemrick, et al., Giardiasis--is it really a zoonosis?, Parasitology Today, 4 (3): 69-71 (1988).
Bulow, et al., Protection of mice from fatal toxoplasma gandii infection by immunization with p30 antigen in liposomes.sup.1, J. of Immun., 147 (10): 3496-3500 (1991).
Buret, et al., Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia, Gastroenterology, 103: 506-513 (1992).
Buret, et al., Growth, activities of enzymes in the small intestine, and ultrastructure of microvillus border in gerbils infected with Giardia duodenalis, Parasitol Res., 77: 109-114 (1991).
Buret, et al., Effects of murine giardiasis on growth, intestinal morphology and disaccharidase activity, J. Parasitol, 76 (3): 403-409 (1990).
Buret, et al., Zoonotic potential of giardiasis in domestic ruminants, J. Infect. Dis., 162: 231-237 (1990).
Butscher, et al., The therpeutic action of monoclonal antibodies against surface glycoprotein of Giardia muris, Immunology, 64: 175-180 (1988).
Buxton, et al., Vaccination of sheep with a live incomplete strain (S48) of toxoplasma gondii and their immunity to challenge when pregnant, Vet. Record, 129: 89-93 (1991).
Capron, et al., Nouvelles approaches moleculaires dans le diagnostic et la prevention de la toxoplasmose, Bull. Acad. Natle. Med., 174 (3): 387-394 (1990) (English version starts on p. 390).
Cesbron-Delauw, et al., Molecular characterization of a 23-kilodalton major antigen secreted by toxoplasma gondii, Proc. Natl. Acad. Sci. USA, 86: 7537-7541 (1989).
Dahl, et al., Recognition by the human immune system of candidate vaccine epitopes of toxoplasma gondii measured by a competitive ELISA, Vaccine, 5: 187-191 (1987).
denHollander, et al., Immunology of Giardiasis, Parasitology Today, 4 (5): 124-130 (1988).
Duquesne, et al., Identification of T cell epitopes within a 23-kD antigen (P24) of toxoplasma gondii, Clin. Exp. Immun., 84: 527-534 (1991).
Escajadillo, et al., Experimental toxoplasmosis and vaccine tests in aotus monkeys, Am. J. Trop. Med. Hyg. 44 (4): 382-389 (1991).
Farthing, et al., Mammalian bile promotes growth of Giardia lamblia in axenic culture, Transactions of The Royal Soc. of Trop. Med. and Hygiene, 77 (4): 467-469 (1983).
Faubert, Evidence that giardiasis is a zoonosis, Parasitology Today, 4 (3): 66-71 (1988).
Feingold, et al., Infect. Immun., 48 (1): 211-218 (1985).
Feely, et al., The biology of Giardia, "Human Parasitic Diseases, 3:--Giardiasis", Meyer Ed., Elsevier Sci. Pub., 11-49 (1990).
Frenkel, et al., Prospective vaccine prepared from a new mutant of toxoplasma gondii for use in cat, Am. J. Vet. Res., 52 (10): 759-763 (1991).
Gazzinelli, Synergistic role of CD4.sup.+ and CD8.sup.+ T lymphocytes in ifny production and protective immunity induced by an attenuated toxoplasma gondii vaccine, J. of Immun., 146 (1): 286-292 (1991).
Gillin, et al., Secretory defenses against Giardia lamblia, Immun. of Milk and the Neonate, Mestecky, et al., Ed., Plenum Press, 227-233 (1991).
Gillin, et al., "Encystation and Expression of Cyst Antigens by Giardia lamblia in Vitro," Science:Materials Science, 235: 1040-1043 (1987).
Gillin, et al., "Small-Intestinal Factors Promote Encystation of Giardia lamblia in Vitro," Infection and Immunity, 56: 705-707 (1988).
Gillin et al., Exp. Parasitol., 69: 164-174 (1989).
Gillon, et al., Changes in the small intestinal mucosa in giardiasis, "Giardia and Giardiasis", Erlandsen, et al., Eds., Plenum Press, 163-183 (1984).
Gottstein, et al., Human cellular immune response to Giardia lamblia, Infec., 19 (6): 421-426 (1991).
Grimwood, et al., Infect. Immun., 42 (3): 1126-1135 (1983).
Halliday, et al., Transact. Royal Soc. Trop. Med. and Hyg., 82: 428-432 (1988).
Hermentin, et al., Efforts towards a vaccine against toxoplasma gondii: a review, Zlb. Bakt. Hyg. A, 269: 423-436 (1988).
Hewlett, et al., Experimental infection of mongrel dogs with Giardia lamblia cysts and cultured trophozoites, J. of Infect. Dis., 145 (1): 89-93 (1982).
Heyworth, Immunology of giardia and cryptosporidium infections, J. of Infec. Dis., 166: 465-472 (1992).
Heyworth, Relative susceptibility of giardia muris trophozoites to killing by mouse antibodies of different isotypes, J. Parasitol., 78 (1): 73-92 (1992).
Hill, et al., Giardia lamblia infection of suckling mice, J. of Infec. Dis., 147 (2): 217-221 (1983).
Holmgren, FEMS Microbiol. Immunol. 89: 1-10 (1991).
Istre, et al., Waterborne giardiasis at a moutain resort: evidence for acquired immunity, Am. J. Pub. Health, 74 (6): 602-604 (1984).
Jakubowski, Purple burps and the filtration of drinking water supplies, Am. J. Pub. Health, 78 (2): 123-125 (1988).
Janoff, et al., The role of immunity in Giardia infections, "Human Parasitic Diseases, 3:--Giardiasis", Meyer Ed., Elsevier Sci. Pub., 215-235 (1990).
Janoff, et al., Acute antibody responses to Giardia lamblia are depressed in patients with AIDS, J. Infec. Dis., 157 (4): 798-804 (1988).
Katelaris, et al., Diarrhoea and malabsorption in giardiasis: a multifactorial process? Gut., 33:295-297 (1992).
Katelaris, et al., Pathogenesis of diarrhea caused by Giardia lamblia: evidence for an exotoxin., J. Gastroenterol. Hepatol., 3 (suppl 1): A4 (1988).
Katelaris, et al., "Bile Modulates Genotypic and Phenotypic Characteristics of Giardia lamblia," Gut, 32: 1089 (1991).
Keister, Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile, Transactions of The Royal Soc. of Trop. Med. and Hygiene, 77 (4): 487-488 (1983).
Kirkpatrick, et al., Feline giardiasis, observations on natural and induced infections, Am. J. Vet. Res., 45 (10): 2182-2188 (1984).
Ko, et al., Identification and characterization of a target antigen of a monoclonal antibody directed against Eimeria tenella morozoites, Molecular and Biochem. Parasitology, 41: 53-64 (1990).
Kum, et al., Indian J. Med. Res. 93: 40-46 (1991).
Lewis, et al., Cortisone-induced recrudescence of Giardia lamblia infections in gerbils, Am. J. Trop. Med. Hyg., 36 (1): 33-40 (1987).
Ljungstrom, et al., Immune response to Giardia lamblia in a water-borne outbreak of giardiasis in Sweden, J. Med. Microbiol., 36: 347-352 (1992).
LoGalbo, et al., Symptomatic giardiasis in three patients with X-linked agammaglobulinemia, J. Pediatrics, 101 (1): 78-80 (1982).
McLeod, et al., Subcutaneous and intestinal vaccination with tachyzoites of Toxoplasma gondii and acquisition of immunity to peroral and congenital toxoplasma challenge, J. of Immun., 140 (5): 1632-1637 (1988).
Marinculic, et al., Immunity in swine inoculated with larvae or extracts of a pig isolate and a sylvatic isolate of Trichinella spiralis, Am. J. Vet. Res., 52 (5): 754-763 (1991).
Mayrhofer, et al., The secretory immune response in rats infected with rodent Giardia duodenalis isolates and evidence for passive protection with immune bile, Adv. in Giardia Res., Wallis, et al., Eds., Univ. Calgary Press, Calgary, Alberta, C
Ceri Howard
Morck Douglas W.
Olson Merle E.
Nelson Brett
Stucker Jeffrey
University Technologies International Inc.
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