Ghrelin variant protein

Details Ghrelin variant protein Ghrelin variant protein

2007-02-13

2007-02-13

Qian, Celine (Department: 1636)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

C930S020000, C930S120000, C536S023510

Reexamination Certificate

active

10659782

ABSTRACT:
The present invention concerns a protein produced from an alternative splice form of the human Ghrelin gene, an obesity and/or diabetes related gene.

REFERENCES:
patent: 6291653 (2001-09-01), Sheppard et al.
patent: 6838438 (2005-01-01), Sheppard et al.
patent: 6967237 (2005-11-01), Bednarek
Gualillo et al. Ghrelin, a novel placental-derived hormone. Endocrinology. vol. 142, No. 2, pp. 788-794, Feb. 2001.
Bednarek et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem. vol. 43, No. 23, pp. 4370-4376, Nov. 2000.
Root et al. Clinical pharmacology of human growth hormone and its secretagogues. Curr Drug Targets Immune Endocr Metabol Disord. vol. 2, No. 1, pp. 27-52, Apr. 2002.
Bednarek et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem. vol. 43, No. 23, pp. 4370-4376, Nov. 2000.
Muccioli et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. vol. 440, No. 2-3, pp. 235-254, Apr. 2002.
Broglio et al. Natural and synthetic growth hormone secretagogues: do they have therapeutic protential? Treat Endocrinol. vol. 2, No. 3, pp. 153-163, 2003.
A. Asakawa, et al., Antagonism of ghrelin receptor reduces food intake and body weight gain in mice, Gut 2003:52:947-952.
Masayasu Kojima et al., Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, vol. 402, Dec. 9, 1999, pp. 656-660.
Hiroshi Hosoda et al., Purification and Characterization of Rat des-Gin14-Ghrelin . . . , J. Biol. Chem., vol. 275, No. 29, Issue of Jul. 21, pp. 21995-22000, 2000.
Mitsuyo Shintani et al., Ghrelin, and Endengenous Growth Hormone Secretagogue . . . , Diabetes, vol. 50, Feb. 2001, pp. 227-232.
P L Jeffery et al., Expression and action of the growth hormone releasing peptide ghrelin . . . , Journal of Endocrinology (2002) 172, Feb 8, 2002, pp. R7-R11.
Minoru Tanaka et al., Testis-specific and developmentally induced expression of a ghrelin . . . , Biochimica et Biophysica Acta, 1522 (2001) pp. 62-65.
L. Trudel et al., Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus . . . , Am J Physiol Gastro Liver Physiol 282: G948-G952, 2002.
Anke Hinney et al., Ghrelin gene: Identification of missense variants and a frameshift mutation . . . , J of Clinical Endocrinology & Metabolism 87(6): 2716-2719 (2002).
Marta Korbonits et al., A variation in the ghrelin gene increases weight and decreases . . . , J of Clinical Endocrinology & Metabolism 87(8): 4005-4008 (2002).
Olavi Ukkola et al., Role of Ghrelin Polymorphisms in Obesity Based on Three Different Studies, Obesity Research vol. 10 No. 8 Aug. 2002 pp. 782-791.
Antonio Torsello et al., Short Ghrelin Peptides Neither Displace Ghrelin Binding In Vitro . . . , Endocrinology 143(5):1968-1971 (2002).
David E. Cummings et al., A Preprandial Rise in Plasma Ghrelin Levels Suggests . . . , Diabetes, vol. 50, pp. 1714-1719, Aug. 2001.
Kazuhiro Kawamura et al., Ghrelin Inhibits the Development of Mouse Preimplantation . . . , Endocrinology 144(6):2623-2633 (2003).
A.M. Wren et al., The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake . . . , Endocrinology vol. 141, No. 11, pp. 4325-4328 (2000).

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