Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2005-11-22
2005-11-22
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S327000, C530S328000
Reexamination Certificate
active
06967237
ABSTRACT:
The present invention features truncated ghrelin analogs active at the GHS receptor. Ghrelin is a naturally occurring modified peptide. The analogs can bind to the GHS receptor and, preferably, bring about signal transduction. Ghrelin analogs have a variety of different uses including being used as a research tool and being used therapeutically.
REFERENCES:
patent: 1 197 496 (2002-04-01), None
patent: 2000WO-JP04907 (2000-02-01), None
patent: WO98/42840 (1998-10-01), None
patent: WO99/63088 (1999-12-01), None
patent: WO01/07475 (2001-02-01), None
Kojima et al., Ghrelin is growth-hormone-releasing acylated peptide from stomach, Dec. 9, 1999, Nature, vol. 402, pp. 656-660.
Dieguez, C. et al. “Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation”, European Journal of Endocrinology, 2000, vol. 142, pp. 413-417.
Bednarek, M. et al. “Structure-Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1 a”, Journal of Medicinal Chemistry, 2000, vol. 43, pp. 4370-4376.
Bluet-Pajot, M-T. et al. “Hypothalamic and Hypophyscal Regulation of Growth Horomone Secreation”, Cellular and Molecular Neurobiology, 1998, vol. 18, pp. 101-104.
Hosoda, H. et al. “Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor”, The Journal of Biological Chemistry, 2000, vol. 275, pp. 21995-22000.
Bowers, C. “Novel GH-Releasing Peptides”, Endocrine Research and Education, Inc., Los Angeles, CA in Molecular and Clinical Advances in Pituitary Disorders, 1993, Chapter 23, pp. 153-157.
Bowers, C. et al., “On the in Vitro and in Vivo Activity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone”, Endocrinology, 1984, vol. 114, pp. 1537-1545.
Chen, C. “Growth Hormone Secretagogue Actions on the Pituitary Gland: Multiple Receptors for Multiple Ligands?”, Clinical and Experimental Pharmacology and Physiology, 2000, vol. 27, pp. 323-329.
Chen, M. et al., “Analogs of the Orally Active Growth Hormone Secretagogue L-162,752”, Bioorganic & Medicinal Chemistry Letters, 1996, vol. 6, pp. 2163-2168.
Cheng, K. et al., “The Synergistic Effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth Hormone (GH)-Releasing Factor-Stimulated GH Release and Intracellular Adenosine 3′,5′-Monophosphate Accumulation in Rat Primary Pituitary Cell Culture”, Endocrinology, 1989, vol. 124, pp. 2791-2798.
Deghenghi, R. et al., “GH-Releasing Activity of Hexarelin, A New Growth Hormone Releasing Peptide, in Infant and Adult Rats”, Life Sciences, 1994, vol. 54, pp. 1321-1328.
Frohman, L. et al., “Growth Hormone-Releasing Hormone”, Endocrine Reviews, 1986, vol. 7, pp. 223-253.
Guan, X. et al., “Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues”, Molecular Brain Research, 1997, vol. 48, pp. 23-29.
Howard, A. et al., “A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release”, Science, 1996, vol. 273, pp. 974-977.
Kineman, R. et al., “Growth Hormone (GH)-Releasing Hormone (GHRH) and the GH Secretagogue (GHS), L692,585, Differentially Modulate Rat Pituitary GHS Receptor and GHRH Receptor Messenger Ribonuleic Acid Levels”, Endocrinology, 1999, vol. 140, pp. 3581-3586.
Kojima, M. et al., “Ghrelin is a growth-hormone-releasing acylated peptide from stomach”, Nature, 1999, vol. 402, pp. 656-660.
Kojima, M. et al., “Ghrelin is a novel growth hormone releasing acylated peptide from stomach”, Third International Symposium on Growth Hormone Secretagogues, Keystone, Colorado, Feb. 17-19, 2000.
Kulju McKee, K. et al., “Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors”, Genomics, 1997, vol. 46, pp. 426-434.
Patchett, A. et al., “Design and biological activities of L-163,191 (MK-0677): A potent, orally growth hormone secretagogue”, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 7001-7005.
Pong, S. et al., “Identification of a New G-Protein-Linked Receptor for Growth Hormone Secretagogues”, Molecular Endocrinology, 1996, vol. 10, pp. 57-61.
Smith, R. et al., “A Nonpeptidyl Growth Hormone Secretagogue”, Science, 1993, vol. 260, pp. 1640-1643.
Strobl, J. et al., “Human Growth Hormone”, Pharmacological Reviews, 1994, vol. 46, pp. 1-34.
Heber Sheldon O.
Merck & Co. , Inc.
Mondesi Robert B.
Tribble Jack L.
Weber Jon
LandOfFree
Ghrelin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ghrelin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ghrelin analogs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3455303