GHL-CU pharmaceutical compositions and compounds

Details GHL-CU pharmaceutical compositions and compounds GHL-CU pharmaceutical compositions and compounds

1992-06-16

1993-05-25

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 6, 514 17, 514 18, 530331, 530329, A61K 3702, C07K 706

Patent

active

052140326

ABSTRACT:
Methods and compositions for (a) stimulating the growth of hair in warm-blooded animals, (b) increasing subcutaneous fat in warm-blooded animals, and (c) increasing the density of hair follicles in warm-blooded animals are disclosed. The methods utilize an effective amount of a composition comprising a derivative of GHL-Cu.

REFERENCES:
patent: 3194732 (1965-09-01), Neuhauser
patent: 3551554 (1970-12-01), Herschler
patent: 3558770 (1971-01-01), Gordon et al.
patent: 3758682 (1973-09-01), Huber et al.
patent: 3767784 (1973-10-01), Gluck
patent: 3832338 (1974-08-01), Huber et al.
patent: 4022888 (1977-05-01), Huber et al.
patent: 4167945 (1979-09-01), Gottlieb
patent: 4177261 (1979-12-01), Dietze et al.
patent: 4263428 (1981-04-01), Apple et al.
patent: 4287184 (1981-09-01), Young
patent: 4440788 (1984-04-01), Terayama et al.
patent: 4665054 (1987-05-01), Pickart
Pickart et al., "Growth-Modulating Tripeptide (glycylhistidylysine): Association with Copper and Iron in Plasma and Stimulation of Adhesive and Growth of Hepatoma Cells in Culture by Tripeptide-Metal Ion Complexes," J. Cell. Physiol., 102(2):129-139, 1980. (Cited in Chem. Abstracts 93:1155m, 1980).
Williams et al., "Glycyl-L-Histidyl-L-Lysine, a Growth Promoting Factor for Human Cells," Cytobios, 27(105):19-25, 1980. (Cited in Chem. Abstracts 94:25451b, 1981).
Mochida Pharmaceutical Co., Ltd., "Antiinflammatory Injections Containing Superoxide Dismutase," Jpn. Kokai Tokkyo Koho, 81 07,720 Jan. 27, 1981. (Cited in Chem. Abstracts, vol. 94: 145386f, 1981).
Kwa, "Glycyl-L-Histidyl-L-Lysine Synthesis of Analogs and NMR Studies," Ph.D. Thesis, University of Washington, 1983.
Loker, "Synthesis of Blood Serum Peptide Cell Growth Factors," Ph.D. Thesis, University of Washington 1980.
Pickart, "The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-Histidyl-L-Lysine," Lymphonkines, 8:425-446, 1983.
Poole et al., "Stimulation of Rat Peritoneal Mast Cell Migration by Tumor-Derived Peptides," Cancer Research, 43:5857-5861, 1983.
Raju et al., "Ceruloplasmin, Copper Ions, and Angiogenesis," JUNCI, 69(5):1183-1188, 1982.
Freedman et al., "Structure of the Glycyl-L-Histidyl-L-Lysine-Copper(II) Complex in Solution," Biochemistry, 21:4540-4544, 1982.
Kwa et al., "PMR Studies of CU(II) and Zn(II) Interaction with Glycyl-L-Histidyl-L-Lysine and Related Peptides," Peptides: Structure and Function, 8, pp. 805-808, 1983.
Perkins et al., "The Structure of a Copper Complex and the Growth Factor Glycyl-L-Histidyl-L-Lysine at 1.1 A Resolution," Inorganica Chimica Acta, 82, pp. 93-99, 1984.
Kimoto et al., "Enhancement of Antitumor Activity of Ascorbate Against the Copper: Glycylglycylhistidine Complex," Cancer Research, 43, pp. 824-828, 1963.
Sorenson, "Copper Complexes: A Physiological Approach to Treatment of Chronic Diseases," Comprehensive Therapy, 11(4):49-64, 1985.
Pickart et al., "Inhibition of the Growth of Cultured Cells and an Implanted Fibrosarcoma by Aroylhydrazone Analogs of the Gly-Hi-Lys-Cu(II) Complex," Biochem. Pharmacol., 32(24), pp. 3868-3871, 1983.
Pickart et al., "Growth-Modulating Plasma Tripeptide May Function by Facilitating Copper Uptake Into Cells," Nature, 288, pp. 815-717, 1980.
Natural Healing Annual 1986, p. 38 (Edit M. Bricklin, Prevention Magazine, Rodale Press, Emmaus, Pa.).
Pickart et al., "A Synthetic Tripeptide which Increases Survival of Normal Liver Cells, and Stimulates Growth in Hepatoma cells," Biochem. Biophys. Res. Commun., 54(2), pp. 526-526, 1973.
Aonuma et al., "Studies on Anti-Ulverogenic Protein in Inflamed Rabbit Skin Tissues," Yakugaku Zasshi 104(4):362-73, 1984.
Downey et al., "Acceleration of Wound Healing using GHL-Cu(II)," Surgical Forum 36:573-75, 1985.
Pckart et al., "A Human Plasma Growth Factor with Superoxide Dismutase-like and Wound-healing Properties," Superoxide Dim. Chem. Biol. Med. Proc. Int. Conf. 4th 1985 (Pub. 1986), 555-57 (Cited in Chem. Abstracts 106:13579c).
Frater-Schroder et al., "Tumor Necrosis Factor Type a Potential Inhibitor of Endothelial Cell Growth in vitro is angiogenic in vivo," Proc. Natl. Acad. Sci. USA 34:5277-81, 1987.
Pickart, "The Use of Glycylhistidyllysine in Culture Systems," In Vitro 17(6):459-66, 1981.

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