Ghilanten antimetastatic principle from the south american leech

Details Ghilanten antimetastatic principle from the south american leech Ghilanten antimetastatic principle from the south american leech

1994-04-06

1995-09-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530856, 530858, A61K 3858, A61K 3817

Patent

active

054479118

ABSTRACT:
A method for the inhibition of tumor metastases is described herein. The method makes use of the administration of an antimetastatic factor isolated from the leech Haementeria ghilianii.

REFERENCES:
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patent: 4588587 (1986-05-01), Gasic
patent: 4832849 (1989-05-01), Cardin
Gasic et al., Cancer Research, 43, 1633-1636 (1983).
J. of the International Society on Thrombosis & Hamosteasis, 61(3), 437-441 (1989), Condra et al.
J. of Biological Chemistry, vol. 262, No. 20, 9718-9723, Tuszynski et al.
G. J. Gasic et al., Proceedings of the American Association for Cancer Research, Los Angeles, Calif., 7-10 May 1987, vol. 27, p. 66, Abstract No. 261.
Brankamp, et al., Ghilantens: Anticoagulant-antimetastatic proteins from the South American leech, Haementeria ghilianii, J. Lab Clin. Med., vol. 115(1), (Jan. 1990).
Blankenship, et al. Biochem. and Biophysical Research Communications, Amino Acid Sequence of Ghilanten: Anticoagulant-Antimetastatic Principle of the South American Leech, Haementeria Ghilianii, vol. 166(3), 1384-1389, (Feb. 14, 1990).
Brankamp, et al., Biochem. and Biophysical Research Communications, Demonstration That [A.sup.103,106, 108 ] Antistasin 93-119 Inhibits the Specific Binding of Antistasin to Sulfatide [Gal(3-SO4).beta.1-1Cer], vol. 181(1), 246-251, (Nov. 27, 1991).
Brankamp, et al., Blood Coagulation and Fibrinolysis, Studies on the anticoagulant, antimetastatic and heparin-binding properties of ghilanten-related inhibitors, vol. 2, 161-166 (1991).

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