GFRα1-RET specific agonists and methods therefor

Details GFRα1-RET specific agonists and methods therefor GFRα1-RET specific agonists and methods therefor

2005-03-15

2005-03-15

Ulm, John (Department: 1646)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C424S185100, C424S184100, C530S350000, C530S399000, C514S002600, C435S377000

Reexamination Certificate

active

06866851

ABSTRACT:
Chimeric GDNF family ligands which activate a GFRα/RET are disclosed. Included are chimeras which activate GFRα1/RET but do not activate GFRα2-RET or GFRα3-RET. The chimeras are useful in providing trophic support to a mammalian cell or in producing differentiation of a mammalian cell, or both, particularly when the cell is in a patient suffering from various diseases, in particular Parkinson's Disease.

REFERENCES:
patent: 5739307 (1998-04-01), Johnson, Jr. et al.
patent: WO 9733911 (1997-09-01), None
patent: WO-9733911 (1997-09-01), None
Skolnick et al., 2000, Tibtech, 18, pp. 34-39.*
Introduction to proteins and protein engineering, 1986, Robson and Garnier, Elsevier, p. 41.*
Jing et al. GFRa2 and GFRa3 are two new receptors for ligands of the GDNF family. J.Biol.Chem., 1997 272, 52, pp. 33111-33117.*
Worby et al. Identification and characterization of GFRa3, a novel Co-receptor belonging to the glial cell line derived neurotrophic receptor family. J.Biol.Chem, 1998 273, 6, pp. 3502-3508.*
Jing et al. GFRa2 and GFRa3 are two new receptors for ligands of the GDNF family. J.Biol.Chem., 272, 52, pp. 33111-33117.*
Worby et al. Identification and characterization of GFRa3, a novel Co-receptor belonging to the glial cell line derived neurotrophic receptor family. J.Biol.Chem, 273, 6, pp. 3502-3508.*
Enokido et al., Current Biology, vol. 8, GFRα -4 and the tyrosine kinase Ret form a functional receptor complex for persephin, pp. 1019-1022, 1998.
Gash et al., Letters To Nature, Functional Recovery In Parkinsonian Monkeys Treated with GDNF, vol. 380, pp. 252-255, Mar. 21, 1996.
Lin et al., Science, GDNF: A Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons, vol. 260, pp. 1130-1132, May 21, 1993.
Trupp et al., The Journal of Cell Biology, Peripheral Expression and Biological Activities of GDNF, a New Neurotrophic Factor for Avian and Mammalian Peripheral Neurons, vol. 130 N0. 1, pp. 137-148, Jul. 1995.
Kotzbauer et al., Letters To Nature, Neurturin, A Relative Of Glial-Cell-Line-Derived Neurotrophic Factor, vol. 384, Dec. 5, 1996.
Tomac,et al., PNAS, Effects of Cerebral Ischemia In Mice Deficient in Persephin, vol. 99, No. 14, pp. 9521-9526, Jul. 9, 2002.
Milbrandt et al., Neuron; Persephin, A Novel Neurotrophic Factor Related to GDNF and Neurturin, vol. 20, pp. 245-253, Feb. 1998.
Cohen, Proc. N.A. S.; 1990 Purification of a Nerve-Growth Promoting Protein From the Mouse Salivary Gland and Its Neuro-Cytotoxic Antiserum, pp. 302-311.
Levi-Montalcini, 1999, Annals NY Academy of Sciences Effects of Mouse Tumor Transplantation On The Nervous System, pp. 330-344.
Baloh et al., TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through RET,Neuron18: 793-802, 1997.
Baloh et al., GFRα3 is an orphan member of the GDNF
euturin/persephin receptor family,Proc. Natl. Acad. Sci., USA 95: 5801-5806, 1998.
Birren et al., Sympathetic neuroblasts undergo a developmental switch in trophic dependence,Development 119: 597-610, 1993.
Bjorklund, Dopaminergic transplants in experimental parkinsonism: cellular mechanisms of graft-induced functional recovery,Current Opinion in Neurobiology 2: 683-689, 1992.
Burmester et al., Mutational Analysis of a Transforming Growth Factor-β Receptor Binding Site,Growth Factors 15: 231-242, 1998.
Burnham, Polymers for delivering peptides and proteins,Am J Hosp Pharm 51: 210-218, 1994.
Creedon et al., Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons,Proc. Natl. Acad. Sci. US 94: 7018-7023, 1997.
Daopin et al., Crystal Structure of Transforming Growth Factor-βB: An Unusual Fold for the Superfamily,Science 257: 369-373, 1992.
Deckwerth and Johnson, Temporal Analysis of Events Associated with Programmed Cell Death (Apoptosis) of Sympathetic Neurons Deprived of Nerve Growth Factor,J. Cell Biol. 123: 1207-1222, 1993.
Eigenbrot and Gerber, X-ray structure of glial cell-derived neurotrophic factor at 1.9A resolution and implications for receptor binding,Nat. Struct. Biol. 4: 435-438, 1997.
Friden et al., Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate,Science 259:373-377, 1993.
Grondin and Gash, Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease,J Neurol. 245(11 Suppl 3): 35-42, 1998.
Hefti, Neurotrophic Factor Therapy for Nervous System Degenerative Diseases,J. Neurobiol. 25: 1418-1435, 1994.
Henderson et al., GDNF: A Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle,Science 266: 1062-1064, 1994.
Heuckeroth et al., Neurturin and GDNF Promote Proliferation and Survival of Enteric Neuron and Glial Progenitors in Vitro,Dev Biol 200: 116-29, 1998.
Jing et al., GDNF-Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF,Cell 85: 1113-1124, 1996.
Jing et al., GFRα-2 and GFRα-3 Are Two New Receptors for Ligands of the GDNF Family,J Biol. Chem. 272: 33111-33117, 1997.
Johnson et al., Dorsal Root Ganglion Neurons Are Destroyed by Exposure in utero to Maternal Antibody to Nerve Growth Factor,Science 210: 916-918, 1980.
Klein et al., A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor,Nature 387: 717-721, 1997.
Kotzbauer et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor,Nature 384: 467-470, 1996.
Lin et al., GDNF: A Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons,Science 260: 1130-1132, 1993.
Milbrandt et al., Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin,Neuron 20: 245-53, 1998.
Miller and Johnson, Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells,J. Neurosci. 16: 7487-7495, 1996.
Molloy et al., Human Furin Is a Calcium-dependent Serine Endoprotease That Recognizes the Sequence Arg-X-X-Arg and Efficiently Cleaves Anthrax Toxin Protective Antigen,J. Biol. Chem. 267: 16396-16402, 1992.
Muller et al., Vascular endothelial growth factor: Crystal and functional mapping of the kinase domain receptor binding site,Proc. Natl. Acad. Sci. U.S.A. 94: 7192-7197, 1997.
Qian et al., Binding Affinity of Transforming Growth Factor-β for Its Type II Receptor Is Determined by the C-terminal Region of the Molecule,J. Biol. Chem. 271: 30656-30662, 1996.
Sanicola et al., Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins,Proc. Natl. Acad. Sci., USA 94: 6238-6243, 1997.
Scully and Otten, NGF: Not Just for Neurons,Cell Biol Int 19: 459-469, 1995.
Suvanto et al., Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptorβ, a homologue to GDNFR-α,Human Molecular Genetics, 1997, vol. 6, No. 8 1267-1273.
Treanor et al., Characterizatin of a multicomponent receptor for GDNF,Nature 382: 80-83, 1996.
Wiesmann et al., Crystal Structure at 1.7 A Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor,Cell 91: 695-704, 1997.
Worby et al., Identification and Characterization of GFRα-3, a Novel Co-receptor Belonging to the Glial Cell Line-derived Neurotrophic Receptor Family,J Biol Chem 273: 3502-3508, 1998.
Worby et al., Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase,J. Biol. Chem.271:23619-23622, 1996.
Xu et al., Characterization of Two Distinct Monoclonal Antibodies Specific for Glial Cell Line-Derived Neurotrophic Factor,J, Neurochem. 70: 1383-1393, 1998.
Davis et al., Enzyme-Polyethylene Glycol Adducts; Rutgers University, 169-173.

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