Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-09-04
2007-09-04
McGarry, Sean (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024300, C536S024330, C536S024500, C435S006120, C435S091100, C435S325000
Reexamination Certificate
active
10029115
ABSTRACT:
The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
REFERENCES:
patent: 6110664 (2000-08-01), Cowsert
patent: 6656716 (2003-12-01), Plowman et al.
patent: 6680170 (2004-01-01), Plowman et al.
patent: WO 01/57190 (2001-08-01), None
Rudinger J in Peptide Hormones. Characteristics of the amino acids as components of a peptide hormone sequence. Editor Parsons JA. pp. 1-7, 1976, University Park Press, Baltimore.
Ippeita et al. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. FEBS Letters, 2000 vol. 469:19-23.
Su, Yi-Chi; “NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain”;The EMBO Journal; 1997; pp. 1279-1290; vol. 16, No. 6; Oxford University Press.
Natoli, Gioacchino, et al.; “Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway”;Science; Jan. 10, 1997; pp. 200-203; vol. 275.
Dan, Ippeita; et al.; “Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development”;FEBS Letters; 2000; pp. 19-23; vol. 469.
Kyriakis, John M.; “Signaling by the Germinal Center Kinase Family of Protein Kinases”;The Journal of Biological Chemistry; Feb. 26, 1999; pp. 5259-5262; vol. 274, No. 9; USA.
Ip, Y. Tony and Roger J. Davis; “Signal transduction by the c-Jun N-terminal kinase (JNK)—from inflammation to development”;Current Opinion in Cell Biology; 1998; pp. 205-219; vol. 10.
Tang et al.: “Nucleic acids encoding polypeptides with cytokine-like activities, useful in diagnosis and gene therapy”; Abstract; Nov. 6, 2001; 3 pages.
Leo Cindy
Luo Ying
Xu Xiang
Yu Simon
Gibbs Terra C.
McGarry Sean
Rigel Pharmaceuticals Inc.
Townsend and Townsend / and Crew LLP
LandOfFree
Germinal center kinase proteins, compositions and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Germinal center kinase proteins, compositions and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Germinal center kinase proteins, compositions and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3785909