Germinal center kinase proteins, compositions, and methods...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S350000

Reexamination Certificate

active

10493164

ABSTRACT:
The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

REFERENCES:
patent: 6110664 (2000-08-01), Cowsert
patent: 6656716 (2003-12-01), Plowman et al.
patent: 6680170 (2004-01-01), Plowman
patent: WO 01/57190 (2001-08-01), None
U.S. Appl. No. 10/029,115, filed Oct. 19, 2001, Ying Luo et al.
Dan, Ippeita, et al.; “Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnasal mouse cerebral development”,FEBS Letters; 2000; pp. 19-23; vol. 469.
IP, Y. Tony and Roger J. Davis; “Signal transduction by the c-Jun N-terminal kinase (JNK)—from inflammation to development”,Current Opinion in Cell Biology; 1998; pp. 205-219; vol. 10.
Kyriakis, John M.; “Signaling by the Germinal Center Kinase Family of Protein Kinases”;The Journal of Biological Chemistry; Feb. 26, 1999; pp. 5259-5262; vol. 274, No. 9; USA.
Natoli, Gioacchino, et al.; “Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway”;Science; Jan. 10, 1997; pp. 200-203; vol. 275.
Su, Yi-Chi et al.; “NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain”;The EMBO Journal; 1997; pp. 1279-1290; vol. 16, No. 6; Oxford University Press.
Tang et al.: “Nucleic acids encoding polypeptides with cytokine-like activities, useful in diagnosis and gene therapy”; Abstract: Nov. 6, 2001; 3 pages.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Germinal center kinase proteins, compositions, and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Germinal center kinase proteins, compositions, and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Germinal center kinase proteins, compositions, and methods... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3879310

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.