Geranylgeranylacetamide compounds having a piperazine ring, salt

Details Geranylgeranylacetamide compounds having a piperazine ring, salt Geranylgeranylacetamide compounds having a piperazine ring, salt

1983-06-06

1985-06-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544386, 544391, A61K 31495, C07D24104

Patent

active

045214174

ABSTRACT:
A geranylgeranylacetamide compound having a piperazine ring represented by the following formula (I) ##STR1## wherein R represents a member selected from the class consisting of a hydrogen atom, C.sub.1 -C.sub.5 alkyl groups which are unsubstituted or mono-substituted by a halogen atom, C.sub.2 -C.sub.5 alkenyl groups and C.sub.7 -C.sub.8 aralkyl groups, R.sub.1 represents a C.sub.1 -C.sub.3 alkyl group, and n represents 0, 1 or 2,
and a pharmaceutically acceptable acid addition salt thereof. The aforesaid compound can be prepared by reacting geranylgeranylacetic acid or its reactive derivative with a piperazine compound, and thereafter, if desired, transforming the free geranylgeranylacetamide compound thus obtained into its pharmaceutically acceptable acid addition salt. A pharmaceutical composition containing said compound exhibits antiulcerogenic activity, particularly excellent antipeptic ulcerogenic activity, and is useful as an agent for treating ulcers.

REFERENCES:
patent: 3646036 (1972-02-01), Laos
patent: 3666780 (1982-05-01), Calame et al.
patent: 4151357 (1979-04-01), Mishima et al.
patent: 4379928 (1982-04-01), Theodoropulos

Affiliated with

Also associated with

Rating

Geranylgeranylacetamide compounds having a piperazine ring, salt does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Geranylgeranylacetamide compounds having a piperazine ring, salt, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Geranylgeranylacetamide compounds having a piperazine ring, salt will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-828258