Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2004-10-01
2008-12-16
Borin, Michael (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C703S011000, C530S350000
Reexamination Certificate
active
07467046
ABSTRACT:
Protein geranylgeranyl transferase type I (GGTase-I), a Ca1a2X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred proteins, including many GTP-binding regulatory proteins (G proteins). The presently disclosed subject matter comprises a plurality of crystal structures of mammalian GGTase-I in complex with substrates and products that provide the first structural information for this enzyme, facilitating the elucidation of a generalized method of action for all protein prenyltransferases; the method includes a role in product transport. The structures reveal specificity determinants that allow classification of putative protein prenyltransferase sequences and can facilitate optimization of GGTase-I and FTase modulators.
REFERENCES:
Qian et al. J. Med. Chem. 1996, 39, 217-223.
Misutani et al (J. Mol. Biol., 1994, 243, 310-326.
Beese Lorena S.
Reid T. Scott
Taylor Jeffrey S.
Borin Michael
Duke University
Jenkins Wilson Taylor & Hunt, P.A.
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