Genotyping assay to predict CYP3A5 phenotype

Details Genotyping assay to predict CYP3A5 phenotype Genotyping assay to predict CYP3A5 phenotype

2006-04-04

2006-04-04

Sitton, Jehanne (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C536S024300

Reexamination Certificate

active

07022475

ABSTRACT:
Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying subjects having a low or high drug metabolizing phenotype associated with CYP3A5 expression are provided. Assays, kits and methods for determining and assaying the CYP3A5 genotype and phenotype of individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's metabolism of drugs and therapeutic agents, the potential for drug interactions, and thereby toxicity and effectiveness of certain drugs and treatment modalities, are provided.

REFERENCES:
patent: WO-02/46209 (2002-06-01), None
patent: WO-02/053775 (2002-07-01), None
Kuehl, P. et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nature Genetics 27:383-391 (Apr. 2001).
ss903337, from NCBI: dbSNP; Sep. 1, 2000.
Smith et al, Xenobiotica, vol. 28, pp. 1129-1165, 1998.
Rootwelt et al; Human Genetics, vol. 94, pp 235-239, 1994.
Genbank Accession No. AC005020 Mar. 21, 2000.
Genbank Accession No. AC005020.4 and AC069294.4 Oct. 6, 2000 dBSNP:SS903337 only.
GenBank Accession No. AC005020.3 and AC069294.3 Sep. 1, 2000 dBSNP rs77b746 only.

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