Genomic morse code

Details Genomic morse code Genomic morse code

2011-07-26

2011-07-26

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

07985542

ABSTRACT:
The present invention relates to a method of detection of the presence of at least one domain of interest on a macromolecule to test, wherein said method comprises the following steps:a) determining beforehand at least two target regions on the domain of interest, designing and obtaining corresponding labeled probes of each target region, named set of probe of the domain of interest, the position of these probes one compared to the others being chosen and forming the specific signature of said domain of interest on the macromolecule to test;b) after spreading of the macromolecule to test on which the probes obtained in step a) are bound, detection of the position one compared to the others of the probes bound on the linearized macromolecule, the detection of the signature of a domain of interest indicating the presence of said domain of interest on the macromolecule to test, and conversely the absence of detection of signature or part of signature of a domain of interest indicating the absence of said domain or part of said domain of interest on the macromolecule to test.

REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4277437 (1981-07-01), Maggio
patent: 4366241 (1982-12-01), Tom et al.
patent: 5800992 (1998-09-01), Fodor et al.
patent: 6040138 (2000-03-01), Lockhart et al.
patent: 6506563 (2003-01-01), Ward et al.
patent: 6927065 (2005-08-01), Chan et al.
patent: 2010/0041036 (2010-02-01), Lebofsky et al.
patent: WO 96/14839 (1996-05-01), None
Molecular Biology Reagents/Protocols 1992, United States Biochemical Corporation, 1991, Cleveland, Ohio, p. 618.
Monier et al, Cytogenet. and Cell Genet. 81 (3-4), 259 (1998).
Anglana et al., 2003, “Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing,” Cell 114, 385-394.
Bensimon et al., 1994, “Alignment and sensitive detection of DNA by a moving interface,” Science 265, 2096-2098.
Berezney et al., 2000, “Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci,” Chromosoma 108, 471-484.
Blow et al., 2005, “Preventing re-replication of chromosomal DNA,” Nat. Rev. Mol. Cell Biol. 6, 476-486.
Brewer et al., 1993, “Initiation at closely spaced replication origins in a yeast chromosome,”. Science 262, 1728-1731.
Cvetic et al., 2005, “Eukaryotic origins of DNA replication: could you please be more specific?”, Semin. Cell Dev. Biol. 16, 343-353.
DePamphilis, M.L., 1999, “Replication origins in metazoan chromosomes: fact or fiction?”, Bioessays 21, 5-16.
Dershowitz et al., 1993, “The effect on chromosome stability of deleting replication origins,” Mol. Cell. Biol. 13, 391-398.
Edenberg et al., 1975, “Eukaryotic chromosome replication,” Ann. Rev. Genet., 9, 245-284.
Edwards et al., 2002, “MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts,” J. Biol. Chem. 277, 33049-33057.
Friedman et al., 1997, “Replication profile ofSaccharomyces cerevisiaechromosome VI,” Genes Cells 2, 667-678.
Gilbert, D.M., 2004, “In search of the holy replicator,” Nat. Rev. Mol. Cell Biol. 5, 848-855.
Hand et al., 1973, “DNA replication: direction and rate of chain growth in mammalian cells,” J. Cell Biol. 58, 410-418.
Hyrien et al., 2003, “Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem,” Bioessays 25, 116-125.
Jun et al., 2004, “Persistence length of chromatin determines origin spacing in Xenopus early-embryo DNA replication: quantitative comparisons between theory and experiment,” Cell Cycle 3, 223-229.
Lebofsky et al., 2005, “DNA replication origin plasticity and perturbed fork progression in human inverted repeats,” Mol. Cell. Biol. 25, 6789-6797.
Lengronne et al., 2002, “The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1),” Mol. Cell 9, 1067-1078.
Lucas et al., 2000, “Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos,” J. Mol. Biol. 296, 769-786.
Lucas et al., 2003, “The dynamics of chromosome replication in yeast,” Curr. Top. Dev. Biol. 55, 1-73.
MacAlpine et al., 2004, “Coordination of replication and transcription along a Drosophila chromosome,” Genes Dev. 18, 3094-3105.
Marheineke et al., 2004, “Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint,” J. Biol. Chem. 279, 28071-28081.
Newlon et al., 1991, “Analysis of a circular derivative ofSaccharomyces cerevisiaechromosome III: a physical map and identification and location of ARS elements,” Genetics 129, 343-357.
Norio et al., 2005, “Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development,” Mol. Cell 20, 575-587.
Pasero et al., 2002; “Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus,” Genes Dev. 16, 2479-2484.
Poloumienko et al., 2001, “Completion of replication map ofSaccharomyces cerevisiaechromosome III,” Mol. Biol. Cell 12, 3317-3327.
Raghuraman et al., 1997, “Cell cycle-dependent establishment of a late replication program,” Science 276, 806-809.
Raghuraman et al., 2001, “Replication dynamics of the yeast genome,” Science 294, 115-121.
Ritzi, 1998, “Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin,” J. Biol. Chem. 273, 24543-24549.
Rothstein et al., 2000, Replication fork pausing and recombination or “gimme a break,” Genes Dev. 14, 1-10.
Santocanale et al., 1996, “ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins inSaccharomyces cerevisiae,” EMBO J. 15, 6671-6679.
Santocanale et al., 1999, “Activation of dormant origins of DNA replication in budding yeast,” Genes Dev. 13, 2360-2364.
Schwob, E., 2004, “Flexibility and governance in eukaryotic DNA replication,” Curr. Opin. Microbiol. 7, 680-690.
Shechter et al., 2004, “ATR and ATM regulate the timing of DNA replication origin firing,” Nat. Cell Biol. 6, 648-655.
Shimada et al., 2002, “ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase,” Genes Dev. 16, 3236-3252.
Shirahige et al., 1993, “Location and characterization of autonomously replicating sequences from chromosome VI ofSaccharomyces cerevisiae,” Mol. Cell. Biol. 13, 5043-5056.
Sorensen et al., 2004, “ATR, Claspin and the Rad9- Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage,” Cell Cycle 3, 941-945.
Syljuasen et al., 2005, “Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage,” Mol. Cell. Biol. 25, 3553-3562.
Tanaka et al., 2002, “Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation,” Genes Dev. 16, 2639-2649.
Todorovic, V., 2005, “Human origins of DNA replication selected from a library of nascent DNA,” Mol. Cell 19, 567-575.
Vujcic et al., 1999, “Activation of silent replication origins at autonomously replicating sequence elements near the HML locus in budding yeast,” Mol. Cell. Biol. 19, 6098-6109.
Walter et al., 1997, “Regulation of replicon size in Xenopus egg extracts,” Science 275, 993-995.
Wyrick et al., 2001, “Genome-wide d

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