Genomic markers of hepatitis B virus associated with...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100, C536S024310, C536S024320

Reexamination Certificate

active

07871780

ABSTRACT:
The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).

REFERENCES:
Blackberg, Jonas et al.; “Mutations Within the Hepatitus B Virus Genome Among Chronic Hepatitus B Patients With Hepatocellular Carcinoma”; 2003,Journal of Medical Virology, vol. 71, pp. 18-23.
Chan, H L-Y et al.; “Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma”; 2004,Gut, vol. 53, pp. 1494-1498.
Cougot, Delphine, et al., :“HBV Induced Carcinogenesis,” 2005,Journal of Clinical Virology, vol. 34, Suppl. 1, pp. S75-S78.
Gao, Jidong et al.; “Close Relation between Hepatocellular Carcinoma and HBV Infection in North China”; 2004,Chin. J. Hepatobiliary Surg., vol. 10, No. 6, 9 pages.
International Search Report from PCT/CN2005/001477, Dec. 15, 2005.
Kao, Jia-Horng, et al, “Basal Core Promoter Mutations of Hepatitis B Virus Increase the Risk of Hepatocellular Carcinoma in Hepatitis B Carriers,” 2003,Gastroenterology, vol. 124, No. 2, pp. 327-334.
Lin, Xu et al., “Structural Analysis of 22 Full-Length Hepatitis B Virus Genomes Isolated from Patients with Hepatocellular Carcinoma”; 2004,Chin. J. Oncol., vol. 26, No. 4, 12 pages.
Tsubota, Akihito, et al., “Genotype May Correlate With Liver Carcinogenesis and Tumor Characteristics in Cirrhotic Patients Infected with Hepatitis B Virus Subtypeadw,” 2001,Journal of Medical Virology, vol. 65, No. 2, pp. 257-265.
Yue, Feng-e et al.; “Relations Between Hepatocellular Carcinoma and HBV Infection”; 2001,China J. Cancer Prev Treat., vol. 8, No. 6, 8 pages.
Zhu, Rong et al.; “Progress in Study on Relations between Hepatitis B Virus X Protein and Hepatocellular Carcinoma”; 2004, Foreign Medical Sciences Epidemiology Lemology, vol. 31, No. 4, 10 pages.

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