Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1993-05-27
1997-04-01
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4353201, 435325, 435354, 435353, 536 232, C12N 510, C12N 1555, C12N 1563, C12P 2100
Patent
active
056164831
ABSTRACT:
The present invention relates to a DNA molecule containing intron sequences and encoding a human protein which is, depending on the site of action, called Bile Salt-Stimulated Lipase (BSSL) or Carboxyl Ester Lipase (CEL). The DNA molecule is advantageously used in the production of recombinant human BSSL/CEL, preferably by means of production in transgenic non-human mammals. The recombinant human BSSL/CEL can be used as a constituent of infant formulas used for feeding infants as a substitute for human milk, or in the manufacture of medicaments against e.g. fat malabsorption, cystic fibrosis and chronic pancreatitis.
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Bjursell Karl G.
Carlsson Peter N. I.
Enerback Curt S. M.
Hansson Stig L.
Lidberg Ulf F. P.
Aktiebolaget Astra
Grimes Eric
Wax Robert A.
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