Genomic DNA exons having exons encoding human pituitary adenylat

Details Genomic DNA exons having exons encoding human pituitary adenylat Genomic DNA exons having exons encoding human pituitary adenylat

1993-06-11

1996-05-28

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 694, 4352402, 4353201, 536 241, C12N 1585, C12N 510

Patent

active

055210694

ABSTRACT:
Disclosed are (1) a genomic DNA of human PACAP38; (2) a DNA containing a DNA segment coding for human PACAP38; (3) a DNA of human PACAP 38 promotor; (4) a transformant carrying a vector which contains a DNA of (3) or further contains a DNA coding for a protein downstream from the promotor; and (5) a method for preparing a protein comprising cultivating the transformant described in the above (4), accumulating the protein in a culture product, and collecting the resulting protein such as mature PACAP 38. The DNA gives human PACAP 38 effectively and makes it possible to screen the chemical substance necessary for production of PACAP and is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. Human PACAP38 can also be utilized as therapeutic agents about growth and maintenance of human brain nerves.

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L. Stryer, "Biochemistry, 3rd Edition" 1988, W.H. Freeman & Co., New York, pp. 117-140.
A. Miyata, et al., Biochem. Biophys. Res. Commun., 170(2):643-648 (1990).

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