Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2007-04-17
2007-04-17
Crouch, Deborah (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S455000, C435S354000, C800S025000
Reexamination Certificate
active
10865424
ABSTRACT:
Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon does not contain the modification are provided. The methods provide for a rapid method for introducing mutations and/or modifications of any type into a mammalian cell genome.
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Davis Samuel
Economides Aris N.
Valenzuela David M.
Yancopoulos George
Crouch Deborah
Gregg, Esq. Valeta
Regeneron Pharmaceuticals Inc.
Sgagias Magdalene K.
Yang Ying-Zi
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