Genital human papillomavirus type 68a (HPV-68a), related to the

Details Genital human papillomavirus type 68a (HPV-68a), related to the Genital human papillomavirus type 68a (HPV-68a), related to the

1997-02-11

1999-11-09

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 71, 4353201, 435 911, 536 2372, 4242041, 4242291, 4241991, C12Q 170, C12P 1934, A61K 3912, C12N 1534

Patent

active

059811730

ABSTRACT:
The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and sequenced. Both types are related to HPV39, a potentially oncogenic virus. HPV68 and HPV70 were also detected in genital intraepithelial neoplasia from three patients and one patient, respectively. Comparison with sequence data in the literature indicates that the subgenomic ME180-HPV DNA fragment, cloned from a carcinoma cell line, corresponds to an HPV68 subtype and that several HPV DNA fragments amplified by PCR from genital neoplasia represent worldwide distributed variants of HPV68 and HPV70.

REFERENCES:
Volpers et al, 1991, Virology, vol. 181, pp. 419-423 1991.
Reuter et al, 1991, Journal of Virology, vol. 65, No. 10, pp. 5564-5568.
Longuet et al, 1996, Journal of Clinical Microbiology, 1996, vol. 34, No. 3, pp. 738-744.

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