Genetically modified tyrosine hydroxylase and uses thereof

Details Genetically modified tyrosine hydroxylase and uses thereof Genetically modified tyrosine hydroxylase and uses thereof

1991-03-13

1993-05-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

4351721, 935 14, C12N 904, C12N 1500

Patent

active

052120821

ABSTRACT:
Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.

REFERENCES:
Lee et al., J. of Neurochem. vol. 53, No. 4, 1989, pp. 1238-1244.
Campbell et al., J. Biol. Chem., vol. 261, No. 23, Aug. 15, 1986, pp. 10489-10492.
Grime et al., Nature, vol. 326, Apr. 16, 1987, pp. 707-711.

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