Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-09-10
2000-06-27
Hutzell, Paula K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 514 44, 514 2, C07H 2104, C07H 2102, A01N 4304
Patent
active
060808497
ABSTRACT:
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors.
REFERENCES:
patent: 4436727 (1984-03-01), Ribi
patent: 5021234 (1991-06-01), Ehrenfeld
patent: 5344762 (1994-09-01), Karapetian
Anderson et al., 1996, "Development of attenuated Salmonella strains that express heterologous antigens," Methods in Molecular Medicine: Vaccine protocols, ed. Robinson A., Farrar G., Wiblin C., Humana Press New Jersey, pp. 47-62.
Engel et al., 1992, "Murein-Metabolizing Enzymes from Escherichia coli: Existence of a Second Lytic Transglycosylase," Journal of Bacteriology, 174(20):6394-6403.
Kelly et al., 1993, "The firA Gene of Escherichia coli Encodes UDP-3-0-(R-3-hydroxymyristoyl)-glucosamine N-Acyltransferase," The Journal of Biological Chemistry, 268(26):19866-19874.
Lindgren et al., 1996, "Macrophage killing is an essential virulence mechanism of Salmonella typhimurium," Proc. Natl. Acad. Sci. USA, 93:4197-4201.
Sizemore et al., 1997, "Interaction of Salmonella typhi Strains with Cultured Human Monocyte-Derived Macrophages," Infection and Immunity, 65(1):309-312.
Adler, 1973, "A Method for Measuring Chemotaxis and Use of the Method to Determine Optimum Conditions for Chemotaxis by Escherichia coli", J. Gen. Microbiol. 74:77-91.
Alizadeh et al., 1994, "Apoptosis as a Mechanism of Cytolysis of Tumor Cells by a Pathogenic Free-Living Amoeba", Infect. Immun. 62:1298-1303.
Bagshawe, 1995, "Antibody-Directed Enzyme Prodrug Therapy: A Review", Drug Dev. Res. 34:220-230.
Barry et al., 1995, "Protection Against Mycoplasma Infection Using Expression-Library Immunization", Nature 377:632-635.
Barth and Morton, 1995, "The Role of Adjuvant Therapy in Melanoma Management", Cancer 75 (Suppl.):726-734.
Berggren, 1995, "Recombinant Salmonella as an Oral HIV Vaccine", NIH Project No. 5 K08 AI01248-02.
Bone, 1993, "Gram-Negative Sepsis: A Dilemma of Modern Medicine", Clin. Microbiol. Rev. 6:57-68.
Bonnekoh et al., 1995, "Inhibition of Melanoma Growth by Adenoviral-Mediated HSV Thymidine Kinase Gene Transfer in vivo", J. Invest. Derm. 104:313-317.
Carey et al., "Clostridial Oncolysis in Man", Eur. J. Cancer 3:37-46.
Carrier et al., 1992, "Expression of Human IL-1.beta. in Salmonella typhimurium; a Model System for the Delivery of Recombinant Therapeutic Proteins in vivo", J. Immunol. 148:1176-1181.
Carswell et al., 1975, "An Endotoxin-Induced Serum Factor that Causes Necrosis of Tumors", Proc. Natl. Acad. Sci. USA 72:3666-3670.
Chabalgoity et al., 1996, "A Salmonella typhimurium htrA Live Vaccine Expressing Multiple Copies of a Peptide Comprising Amino Acids 8-23 of Herpes Simplex Virus Glycoprotein D as a Genetic Fusion to Tetanus Toxin Fragment C Protects Mice from Herpes Simplex Virus Infection", Mol. Microbiol. 19:791-801.
Christ et al., 1995, "E5531, a Pure Endotoxin Antagonist of High Potency", Science 268:80-83.
Clements, 1995, "Attenuated Salmonella as Vaccine Vectors", NIH Project No. 5 R01 AI 28835-06.
Clementz et al., 1997, "Function of the Escherichia coli msbB Gene, a Multicopy Suppressor of htrB Knockouts, in the Acylation of Lipid A", J. Biol. Chem. 272(16):10353-10360.
Cunningham et al., 1992, "Actin-Binding Protein Requirement for Cortical Stability and Efficient Locomotion", Science 255:325-327.
Curtiss, 1995, "Biological Containment of Live Bacterial Vaccines", NIH Project No. 1 R41 AI38599-01.
Curtiss, 1994, "Avirulent Salmonella Host-Vector Vaccine Systems", NIH Project No. 1 R41 AI36585-01.
Eisenstadt, 1987, "Analysis of Mutagenesis", from Escherichia coli and Salmonella typhimurium, Cellular and Molecular Biology, Neidhardt et al. (ed.), pp. 1016-1033.
Eisenstein et al., 1995, "Immunotherapy of a Plasmacytoma with Attenuated Salmonella", Med. Oncol. 12:103-108.
Engelbart and Gericke, 1963, "Oncolysis by Clostridia. V. Transplanted Tumors of the Hamster", Cancer Res. 24:239-243.
Falkow, 1991, "Bacterial Entry into Eukaryotic Cells", Cell 65:1099-1102.
Fox et al., 1996, "Anaerobic Bacteria as a Delivery System for Cancer Gene Therapy: in vitro Activation of 5-Fluorocytosine by Genetically Engineered Clostridia", Gene Therapy 3:173-178.
Friberg, 1993, "BCG in the Treatment of Superficial Cancer of the Bladder: A Review", Med. Oncol. Tumor Pharmacother. 10:31-36.
Galan, 1995, "Novel Salmonella Antigen Delivery Vectors", NIH Project No. 5 R01 AI36520-02.
Gericke and Engelbart, 1963, "Oncolysis by Clostridia. II. Experiments on a Tumor Spectrum with a Variety of Clostridia in Combination with Heavy Metal", Cancer Res. 24:217-221.
Gulig, 1994, "Salmonella typhimurium Virulence Plasmid", NIH Project No. 5 R29 AI28421-05.
Hall et al., 1994, "Induced Regression of Bovine Papillomas by Intralesional Immunotherapy", Therapeutic Immunol. 1:319-324.
Han et al., 1967, "Salmonellosis in Disseminated Malignant Diseases", New Eng. J. Med. 276:1045-1052.
Jain, 1994, "Barriers to Drug Delivery in Solid Tumors", Sci. American 271:58-65.
Jones et al., 1992, "Invasion by Salmonella typhimurium is Affected by the Direction of Flagellar Rotation", Infect. Immun. 60:2475-2480.
Karow and Georgopoulos, 1992, "Isolation and Characterization of the Escherichia coli msbB Gene, a Multicopy Suppresssor of Null Mutations in the High-Temperature Requirement Gene htrB", J. Bacteriol. 174:702-710.
Klimpel et al., 1990, "Bacteria-Infected Fibroblasts have Enhanced Susceptibility to the Cytotoxic Action of Tumor Necrosis Factor", J. Immunol. 145:711-717.
Lee et al., 1992, "Identification of a Salmonella typhimurium Invasion Locus by Selection for Hyperinvasive Mutants", Proc. Natl. Acad. Sci. USA 89:1847-1851.
Lemmon et al., 1994, "Anaerobic Bacteria as a Gene Delivery System to Tumors", Proc. Am. Assn. Cancer Res. 35:374 (Abstract 2231).
Lemmon et al., 1997, "Anaerobic Bacteria as a Gene Delivery System that is Controlled by the Tumor Microenvironment", Gene Therapy, 4:791-796.
Levine, 1995, "Recombinant and Live Oral Salmonella typhi Vaccines", NIH Project No. 5 R01 AI29471-06.
Loppnow et al., 1990, "Cytokine Induction by Lipopolysaccharide (LPS) Corresponds to Lethal Toxicity and is Inhibited by Nontoxic Rhodobacter capsulatus LPS", Infect. Immun. 58:3743-3750.
Lytvyn et al., 1992, "Comparison of the Thymidine Kinase Genes from Three Entomopoxviruses", J. Gen. Virol. 73:3235-3240.
Macnab, 1992, "Genetics and Biogenesis of Bacterial Flagella", Ann. Rev. Genet. 26:131-158.
Mahan et al., 1993, "Selection of Bacterial Virulence Genes that are Specifically Induced in Host Tissues", Science 259:686-688.
McLaughlin et al., 1979, "Synergistic Activity of Components of Mycobacteria and Mutant Salmonella in Causing Regression of Line-10 Tumors in Guinea Pigs", Cancer Res. 39:1766-1771.
Michalek, 1994, "Genetically Engineered Oral Vaccines and Caries Immunity", Abstract, NIH Project No. 5 R01 DE09081-05.
Miller et al., 1989, "A Two-Component Regulatory System (phoP phoQ) Controls Salmonella typhimurium Virulence", Proc. Natl. Acad. Sci. USA 86:5054-5058.
Miller, 1995, "Entry into Eukaryotic Cells by Salmonella and Yersinia", NIH Project No. 5 K04 AI01230-02.
Miller et al., 1992, "An Unusual pagC::TnphoA Mutation Leads to an Invasion- and Virulence-Defective Phenotype in Salmonellae", Infect. Immun. 60:3763-3770.
Minton et al., 1995, "Chemotherapeutic Tumour Targeting Using Clostridial Spores", FEMS Micro. Rev. 17:357-364.
Mose and Mose, 1963, "Oncolysis by Clostridia. I. Activity of Clostridium butyricum (M-55) and Other Nonpathogenic Clostridia Against the Ehrlich Carcinoma", Cancer Res. 24:212-216.
Mullen et al., 1992, "Transfer of the Bacterial Gene for Cytosine Deaminase to Mammalian Cells Confers Lethal Sensitivity to 5-Fluorocytosine: a Negative Selection System", Proc. Natl. Acad. Sci USA 89:33-37.
Nauts et al., 1953, "A Review of the Influence of Bacterial Infection and of Bacterial Products (Coley's Toxins) on Malignant Tumors in Man", Acta Medica Scandinavica 145 (
Bermudes David
Low Kenneth Brooks
Hutzell Paula K.
Sun-Hoffman Lin
Vion Pharmaceuticals Inc.
Yale University
LandOfFree
Genetically modified tumor-targeted bacteria with reduced virule does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genetically modified tumor-targeted bacteria with reduced virule, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetically modified tumor-targeted bacteria with reduced virule will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1785500