Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-12-12
2010-06-29
Ton, Thaian N (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S008000, C800S003000
Reexamination Certificate
active
07745691
ABSTRACT:
Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
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Cases Sylvaine
Chen Hubert C.
Erickson Sandra K.
Farese, Jr. Robert V.
Smith Steven J.
Borden Paula A.
Bozicevic Field & Francis LLP
Noble Marcia S
The J. David Gladstone Institutes
The Regents of the University of California
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