Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2005-07-08
2009-11-17
Haddad, Maher M (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S366000, C435S372200
Reexamination Certificate
active
07618817
ABSTRACT:
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ, TCR-ζ, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.
REFERENCES:
patent: 3773919 (1973-11-01), Borwell et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5767077 (1998-06-01), Peltz et al.
patent: 5830725 (1998-11-01), Nolan et al.
patent: 5976831 (1999-11-01), Peltz et al.
patent: 7038031 (2006-05-01), Ravetch et al.
patent: 0758394 (1997-02-01), None
patent: WO 91/00360 (1991-01-01), None
patent: WO 92/20373 (1992-11-01), None
patent: WO 97/33551 (1997-09-01), None
patent: WO 98/49268 (1998-04-01), None
Mandelboim et al. PNAS 1999. 96:5640-5644.
Swiss-Prot variant: VAR—008801 in P08637. Jan. 27, 2008. pp. 1-2.
Deaglio, S. et al., Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells, BLOOD vol. 99, No. 7, Apr. 1, 2002, p. 2490-2498.
Mandelboim, O. et al., Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity, Proc. Natl. Acad. Sci. vol. 96, p. 5640-5644, May 1999.
Zhang, J. et al., Characterization of interleukin-15 gene-modified human natural killer cells: implications for adoptive cellular immu., Haematologica, 89(3), p. 338-347, Mar. 2004.
Zhang, J. et al., Characterization of stem cell factor gene-modified human natural killer cell line . . . , Oncology Reports 11: 1097-1106, 2004.
Ernst, L. et al., Allelic polymorphisms in the FcyRIIC gene can influence Its function on normal human natural killer cells, J. Mol. Med. 80:248-257, 2002.
Altschul, S. et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nuc. Acids Res. 1997, vol. 25(17): 3389-3402.
Austin, C. et al., Cellular migration patterns in the developing mouse cerebral cortex, Development 110: 713-732, 1990.
Boerner, P. et al., Production of antigen-specific human monoclonal antibodies from in vitro-primed human splenocytes, J. Immunol. 147(1): 86-95, 1991 (abstract only).
Brennan, M. et al., Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobuln G1 fragments, Science 229 (4708): 81-83, Jul. 5, 1985 (abstract).
Campbell, K. et al., NKp44 triggers NK cell activation through DAP12 association . . . , J. Immunol., 172: 900-906, 2004.
Capecchi, M., High efficiency transformation by direct microinjection of DNA into cultured mammalian cells, Cell vol. 22(2): 479-488, Nov. 1980 (abstract).
Carter, P., Site-directed mutagenesis, Biochem. J. 237: 1-7, 1986.
Cepko, C. et al., Construction and applications of a highly transmissible murine retrovirus shuttle vector, Cell vol. 37(3): 1053-1062, Jul. 1984 (abstract).
Chaney, W. et al., High-frequencey transfection of CHO cells using polybrene, Somatic Cell and Mol Gene, vol. 12(3): 237-244, May 1986 (abstract).
Clark, J. et al., Induction of multiple anti-c-erbB-2 specificities accompanies a classifical idotypic . . . , Can Immuno vol. 44(5): 265-22, Jul. 1997 (abstract).
Elroy-Stein, O. et al., Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase . . . , Pro. Natl. Acad. Sci. 8:6743-6747, 1990 (abstract).
Escudero, J. et al., Transfer and integration of T-DNA without cell injury in the host plant, The Plant Cell, vol. 9(12): 2135-2142, 1997 (abstract).
Fekete, DM et al., Retroviral infection coupled with tissue transplatnation limits gene transfer in the chicken embryo, Pro. Natl. Acad. Sci. 90: 2350-2354, 1993 (abstract).
Feigner, P. et al., Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure, Proc. Natl. Acad. Sci. vol. 84(21): 7413-7417, Nov. 1987 (abstract).
Fieck, A. et al., Modifications of theE. coliLac repressor for expression in eukaryotic cells: effects of nuclear signal . . . , Nuc Acids Res 20(7): 1785-1791, 1992.
Fishwild, D. M. et al., High-avidity human IgGk monoclonal antibodies from a novel strain of minilocus transgenic mice, Nature Biotechnology 14: 845-857, 1996 (abstract).
Fleit, H.B. et al., Human neutrophil Fc, receptor distribution and structure, Proc. Natl. Acad. Sci. 79: 3275-3279, 1982.
Fujita, T. et al., Regulation of human interleukin-2 gene: functional DNA sequences in the 5′ flanking region for the gene . . . , Cell 46(3): 401-407, 1986 (abstract).
Gerstmayer, B. et al., Stable expression of the ecotroplc retrovirus receptor in amphotropic packaging cells . . . , J. Viro. Meth. 81(1-2): 71-75, 1999 (abstract).
Gong, L. et al., Characterization of a human cell line (NK-92) wih phenotypical and functional characeristics of activated natural killer cells, Leukemia 8(4): 652-658, 1994.
Gruber, M. et al., Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed inEscherichia coli, J. Immunol. 152(11): 5368-5374, 1994 (abstract).
Holliger, P. et al., Diabodies: small bivalent and bispecific antibody fragments, Proc. Natl. Acad. Sci. 90: 6444-64484, 1993.
Hoogenboom, H. et al., Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying . . . , Nuc. Acids Res. 19(15): 4133-4137, 1991 (abstract).
Huang, J. et al., The emotif database, Nuc. Acids Res. 2991): 202-204, 2001.
Ishiura, M. et al., Phage particle-mediated gene transfer to cultured mammalian cells, Mol. Cell Bio. 2(6): 607-616, 1982 (abstract).
Jones, P. et al, Replacing the complementarity-determing regions in a human antibody with those from a mouse, Natre 321: 522-525, 1986 (abstract).
Kawai, S. et al., New procedure for DNA transfection with polycation and dimetyl sulfoxide, Mol Cell Biol 4(6): 172-174, 1984 (abstract).
Kikuchi-Maki, A. et al., KIR2DL4 is an IL-2-Regulated NK cell receptor that exhibits limited expression in humans. . . , J. Immunol. 171: 3415-3425, 2003.
Kinsella, TM. et al., Episomal vectors rapidly and stably produce high-titer recombinant retrovirus, Hum Gene Ther 7(12): 1405-1413, 1996 (abstract).
Koene, H. et al., RcaRIIIa-158V/F polymorphism influces the binding of IgG by natural killer cell . . . , Blood 90(3): 1109-1114, 1997.
Kostelny, SA et al., Formation of a bispecific anitbody by the use of leucine zippers, J. Immunol. 148(5): 1547-1553, 1992 (abstract).
Lam, K., Mini-review: application of combinatorial library methods in cancer research and drug discovery, Anti-Cancer Drug Design 12(3): 145-167, 1997 (abstract).
Lemischka, I. et al., Developmental potential and dynamic behavior of hematopietic stem cells, Cell 45(6): 917-927, 1986 (abstract).
Linder, M. et al., Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency, Clin. Chem. 43: 254-266, 1997.
Lonberg, N. et al., Antigen-specific human antibodies from mice comprising four distinct genetic modifications, Nature 368: 856-859, 1994 (abstract).
Lopata, M. et al., High level transient expression of a chloramphenicol acetyl transferase gene . . . , Nuc. Acids Res. 12(14): 5707-5717, 1984 (abstract).
Maki, G. et al., Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92, J Hematother Stem Cell Res, 10(3): 369-383, 2001 (abstract).
Marasco, W. et al., Design, intracellular expression, and activity of a human anti-human Immunodeficiency virus type . . . , Proc. Natl. Acad. Sci. 90: 7889-7893, 1993.
Marks, J. et al., By-passing immunization: Human antibodies from V-gene libraries displayed on phage, J. Mol. Biol. 222(3): 581-597, 1991 (abstract).
Miller, A. et al., Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production, Mol. & Cell. Biol. 6(8): 2895-2902, 1986.
Milstein, C. et al., Hybr
Cohen & Grigsby P.C.
Dahle Chun
Fox Chase Cancer Center
Haddad Maher M
Passerin, Esq. Alicia M.
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