Genetically modified cyclic-nucleotide controlled ion...

Details Genetically modified cyclic-nucleotide controlled ion... Genetically modified cyclic-nucleotide controlled ion...

2002-08-06

2008-08-26

Li, Ruixiang (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S004000, C435S006120, C435S069100

Reexamination Certificate

active

07417117

ABSTRACT:
The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits have been altered so as to have higher sensitivity to cAMP and/or higher selectivity for cAMP compared to cGMP in comparison with the wild type according to SEQ ID NO 1 and 2.

REFERENCES:
patent: WO 99/42574 (1999-08-01), None
Altenhofen et al., Control of ligand specification in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium. Proc. Natl. Acad. Sci. USA 88:9868-9872, 1991.
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M.D. Varnum et al; Molecular Mechanism for Ligands Dis . . . ; Neuron, vol. 15, Sep. 1995; 619-625.
U. B. Kaupp; R. Selfert; Molecular Diversity of Pacemaker Ion . . . ; Annu. Rev Physiol 2001, 235-257.
I.T. Weber; T.A. Steltz; Structure of a Complex of Catabolite Gene . . . ; J. Mol. Biol. 1987; 311-326.
W. Altenhofen; J. Ludwig et al; Control of Ligand Specificity . . . Proc. Natl. Acad. Sci. 1991; 9868-9872.
J.B. Shabb, B.D. Buzzeo et al; Mutating Protein Kinase cAMP- . . . ; Jour.Biol.Chem. 1991; 24320-24326.
U.B. Kaupp; The Cyclic Nucleotide-gated Channels . . . ; Trends in Neurosciences 1991; 150-157.
J. Ludwig et al; Primary Structure at Cyclic . . . ; FBS Letters, Elsevier Science Pub.; No. 1-2; 1990; 24-29.
U.B. Kaupp et al; Cyclic Nucleotide Gated Ion Ch . . . ; Physiological Reviews; No. 3, Jul. 2002; 769-824.

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