Genetically modified cells expressing a TGFβ...

Details Genetically modified cells expressing a TGFβ... Genetically modified cells expressing a TGFβ...

2006-09-05

2006-09-05

Epps-Ford, Janet L. (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S093200, C435S325000

Reexamination Certificate

active

07101543

ABSTRACT:
The present invention relates to compositions comprising a therapeutically effective amount of genetically modified cells containing a genetic construct expressing a TGFβ inhibitor effective to reduce expression of TGFβ, where the genetically modified cells are non-small cell lung cancer (NSCLC) cells or small cell lung cancer (SCLC) cells, and related methods.

REFERENCES:
patent: 5772995 (1998-06-01), Fakhrai et al.
patent: 6120763 (2000-09-01), Fakhrai et al.
patent: 6447769 (2002-09-01), Fakhrai et al.
patent: 0695 354 (2002-01-01), None
patent: WO 93/07906 (1993-04-01), None
patent: WO 94/25588 (1994-11-01), None
patent: WO 96/02143 (1996-02-01), None
patent: WO 96/25178 (1996-08-01), None
patent: WO 01/74404 (2001-10-01), None
Goodman and Gilman's The Pharmacological Basis of Therapeutics. Ninth Edition McGraw-Hill 1996 pp. 77-101.
Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Decomber 1995 p. 11.
Gene Therapy's Growin Pains, Science. 1995, 25:1050, 1052-5.
Schwartzentruber et al., Blood. Aug. 15, 1993;82(4)1204-11.
Shandhu et al., Human Gene Therapy, Critical Reviews in Biotechnology 1997 17:307-326.
Sobol et al., Interleukin 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: a Phase I study, Clin Cancer Res. 1999 5:2359-65.
Fakhrai et al., Gene Therapy of Human Gliomas with TGF-beta2 Antisense Gene Modified Autologous Tumor Cells. A Phase I Clinical Trial. Proceedings of the American Association for Cancer Research Annual Meeting (Mar. 2000) No. 41, pp. 543.
Sharma et al., Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and . Gene Ther. 1997 4:136-70.
Fakhrai, H., et al., “Immunization with TGF-B2 Antisense Gene Modified Tumor Cells Eradicates Intracranial Gilomas,” Proceedings of the Annual Meeting of the American Association for Cancer Research , vol. 36, pp. 463-E (1995).
Fischer, J.R., et al., “Constitutive Secretion of Bioactive Transforming Growth Factor β1by Small Cell Lung Cancer Cell Lines,” European Journal of Cancer, vol. 30A, No. 14, pp. 2125-2129 (1994).
Norgaard, P., et al., “Expression and autoregulation of transforming growth factor β receptor mRNA in small-cell lung cancer cell lines,” British Journal of Cancer, vol. 73, No. 9, pp. 1037-1043 (1996).
Asselin-Paturel, C., et al., “Quantitative Analysis of Th1, Th2 and TGF-β1 Cytokine Expression in Tumor, Til and PBL of Non-Small Cell Lung Cancer Patients,” International Journal of Cancer, vol. 77, No. 1, pp. 7-12 (1998).
Fakhrai et al., “Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy,” Proc Natl Acad Sci USA 93: 2909 (1996).
Ogawa and Seyedin, “Purification of Transforming Growth Factors β1 and β2 from Bovine Bone and Cell Culture Assays,” Meth Enzymol 198: 317 (1991).

Affiliated with

Also associated with

Rating

Genetically modified cells expressing a TGFβ... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetically modified cells expressing a TGFβ..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetically modified cells expressing a TGFβ... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3544137