Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-03-24
1994-11-15
Ellis, Joan
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 693, 4351723, 4352351, 435236, 4352401, 530300, 530350, 4242051, 4242321, 935 32, 935 65, 935 70, C12P 2102, C12P 1934, C12N 1500, C12N 700
Patent
active
053647734
ABSTRACT:
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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Hom
Paoletti Enzo
Perkus Marion E.
Ellis Joan
Tuscan Michael S.
Virogenetics Corporation
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