Genetically engineered organisms expressing surface proteins of

Details Genetically engineered organisms expressing surface proteins of Genetically engineered organisms expressing surface proteins of

1983-09-30

1986-10-07

Hazel, Blondel

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351723, 435317, 935 12, 935 29, 935 38, 935 56, 935 65, 536 27, 424 88, 530395, A61K 39005, C12P 2100, C12N 1500, C12M 102

Patent

active

046159738

ABSTRACT:
Genetically engineered plasmids which express DNA encoding for insect stage specific glycoproteins of Trypanosoma cruzi are disclosed. The glycoproteins offer potential diagnostic utility for the detection of Chagus disease.

REFERENCES:
patent: 4466917 (1984-08-01), Nussenzweig et al.
Nogueira et al., Proc. Natl. Acad. Sci., vol. 79(2), pp. 1259-1263, Feb. 1982, "Specific Glycoprotein Antigens on the Surface of Insect and Mammalian Stages of Trypanosoma cruzi".
Pawlowski et al., J. Biol. Chem., vol. 250(6), pp. 325-375, "Identification and Purification of Collagen-Synthesizing Polysomes with Anti-Collagen Antibodies".
Hopp et al. Proc. Nat. Acad. Sci., vol. 78(6), pp. 3824-3828, Jun. 1981, "Prediction of Protein Antigenic Determinants from Amino Acid Sequences".
Pays et al. Chem. Abst., vol. 9Y, No. 99583t, 1981, "Cloning and Characterization of DNA Sequencer Complementary . . . of Trypanosoma brucei".

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