Genetically engineered mice containing alterations in the MHC cl

Details Genetically engineered mice containing alterations in the MHC cl Genetically engineered mice containing alterations in the MHC cl

1994-10-03

1997-07-01

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, C12N 1500

Patent

active

056440650

ABSTRACT:
The present invention provides mice which are deficient in the normal expression of one or more MHC class II genes, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous, homozygous or chimeric for such deficiency, as well as to the use of any of the above, especially in situations where the absence of at least one MHC gene, or the normal expression thereof, is desirable.

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