Genetically engineered mice containing alterations in the genes

Details Genetically engineered mice containing alterations in the genes Genetically engineered mice containing alterations in the genes

1995-12-29

2000-02-29

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435477, 435463, 435 6, 435 911, 435354, 435375, 435377, 424 921, C12N 500, C12N 1500, C12N 1509, C12N 1563

Patent

active

060311495

ABSTRACT:
The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.

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