Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-08-19
2000-07-25
Campbell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 3, 800 21, 800 22, 800 25, 435455, 435463, 435462, 435325, 4353201, 435 4, C12N 1509, C12N 1500, C12N 1563, C12N 500
Patent
active
060938730
ABSTRACT:
The present invention is directed to mice which are genetically altered to be deficient in the normal expression of RXR.gamma., to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The invention further provides mice and cell lines which, in addition to being deficient in RXR.gamma., are genetically altered to be deficient in the expression of RXR.alpha. and/or RXR.beta.. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of RXR.gamma., or the normal expression thereof, is desirable.
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Chambon Pierre
Kastner Philippe
Bristol--Myers Squibb Company
Campbell Bruce R.
Centre National de la Recherche Scientifique
Institut National de la Sante et de la Recherche Medicale
Martin Jill D.
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