Genetically-engineered MHC molecules

Details Genetically-engineered MHC molecules Genetically-engineered MHC molecules

2008-01-15

2008-01-15

Chan, Christina (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023500, C435S325000, C530S402000, C530S403000

Reexamination Certificate

active

10297060

ABSTRACT:
The invention provides DNA molecules encoding a chimeric polypeptide comprising (a) a component of a MHC molecule capable of association on a cell surface with an endogenous MHC molecule component of the same class, and (b) an intracellular region of a signal transduction element capable of activating T cells. Component (a) may be a monomorphic component and is preferably beta 2-microglobulin, or a polymorphic class I or class II component. The signal transduction element (b) capable of activating T cells may be a component of T-cell receptor CD3, preferably the CD3 zeta (zeta) polypeptide, a B cell receptor polypeptide or an Fc receptor polypeptide. Immune cells such as a CTLs expressing said chimeric MHC molecules specifically eliminate or inactivate harmful T cells and are useful for treating graft rejection and autoimmune diseases.

REFERENCES:
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patent: WO 97/08328 (1997-03-01), None
patent: WO 97/20938 (1997-06-01), None
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