Genetically engineered low oxygen affinity mutants of human hemo

Details Genetically engineered low oxygen affinity mutants of human hemo Genetically engineered low oxygen affinity mutants of human hemo

1994-04-28

1995-06-27

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 723, 435 691, 435 696, 4351723, 4352402, 4352523, 4353201, 514 2, 514 12, 530350, 530385, 536 221, 536 231, 536 235, A61K 3816, C12N 500, C12P 2106, C07H 1900

Patent

active

054280079

ABSTRACT:
Peptides encoded by a substantially pure polynucleotide coding for an alpha and/or beta human globin, the globin when part of a hemoglobin molecule conferring lower oxygen affinity than normal hemoglobin to result in a mutant hemoglobin, the mutant hemoglobin having an oxygen affinity measured for stripped hemoglobin characterized by a P.sub.50 of 30 torr to 3 atmospheres and/or by a Hill coefficient between 2.5 and 1.0. Such mutant hemoglobin being useful to increase tissue oxygenation in a patient, to replace hemoglobin in the bloodstream of a patient and to treat patients suffering from burns.

REFERENCES:
patent: 5028588 (1991-07-01), Hoffman et al.
Brunori et al. "A macromolecular transducer . . . " PNAS 75, 9 4310-4312.
Fischer et al. "Perfluorochemicals . . . " Int. J. Radiation Onc. Biol. Phys. 12 pp. 95-102 1986.
Sidney V. Suggs, et al, "Use of Synthetic Oligonucleotides as Hybridization Probes: Isolation of Cloned cDNA Sequences for Human .sup..beta..sub.2 -microglobulin", Proc. Natl. Acad. Sci. USA, vol. 78, No. 11, pp. 6613-6617, Nov. 1981.
F. Bossa et al, "Primary Structure of Hemoglobins From Trout (Salmo Irideus), Partial Determination of Amino Acid Sequence of HB Trout IV", vol. 64, No. 1, FEBS Letters, Apr. 1976, pp. 76-79.
E. Fioretti et al, "Preparation of Apohemoglobin Trout IV and Reconstitution With Different Hemes", vol. 68, No. 4, 1976, pp. 1169-1173, Biochemical And Biophysical Research Communications.
Richard Earl Dickerson, "Hemoglobin: structure, function, evolution, and pathology", Chapter 4, Abnormal Human Hemoglobins, pp. 148-157, 1983.

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