Genetically engineered cells that produce produce L. Dopa

Details Genetically engineered cells that produce produce L. Dopa Genetically engineered cells that produce produce L. Dopa

1994-08-12

2000-08-15

LeGuyader, John I.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 691, 435440, 435455, 435325, 435375, A61K 3500, A61K 4800, C12N 1585, C12N 1500

Patent

active

061032263

ABSTRACT:
The present invention provides a process of increasing dopamine production in a cell comprising co-transfecting the cell with one or more expression vectors containing polynucleotides that encode tyrosine hydroxylase, aromatic L-amino acid decarboxylase and GTP cyclohydrolase. Cells transfected with such vectors and the use of such transformed cells to increase dopamine production in the central nervous system of animals are also provided.

REFERENCES:
patent: 5082670 (1992-01-01), Gage et al.
Chen et al.; "Cellular Replacement Therapy for Neurologic Disorders: Potential of Genetically Engineered Cells"; Journal of Cellular Biochemistry, vol. 45, pp. 252-257, 1991.
Wolff et al.; "Grafting Fibroblasts Genetically Modified to Produce L-DOPA in a Rat Model of Parkinson Disease"; Proceedings of the National Academy of Sciences USA, vol. 86, pp. 9011-9014, Nov. 1989.
Sumi et al.; "Characterization of Recombinant Human Aromatic L-Amino Acid Decarboxylase Expressed in COS Cells"; Journal of Neurochemistry, vol.55, No. 3, pp. 1075-1078, 1990.

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