Genetically engineered alpha helix polypeptide

Details Genetically engineered alpha helix polypeptide Genetically engineered alpha helix polypeptide

1996-11-20

2000-09-26

Nashed, Nashaat

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530326, G03C 500

Patent

active

061244295

ABSTRACT:
A polypeptide having .alpha.-helix structure, which has a hydrophilic surface and a hydrophobic surface, and which is produced by genetic engineering techniques is disclosed. According to the present invention, stable polypetide molecules having .alpha.-helix structure, which have a constant molecular weight and which can be used in various applications represented by materials for medical applications, can be provided.

REFERENCES:
patent: 4514331 (1985-04-01), Kaiser et al.
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patent: 4939224 (1990-07-01), Musso et al.
patent: 5374531 (1994-12-01), Pang et al.
patent: 5789542 (1998-08-01), McLaughlin et al.
Chou et al. "Empirical predictions of protein conformation" Ann. Rev. Biochem. 47, 251-276, 1978.
Kaiser et al. "Secondary structure of proteins and peptides in amphiphlic enviroments (a review)" Proc. Natl. Acad. 80, 1137-1143, Feb. 1983.
Moe et al,"Design, synthesis, and characterization of a model peptide having potent calcitonin-like biological activity: implications for calcitonin structure/activity" Biochemistry 24, 1971-1976, 1985.
Minakata et al, "Characteristics of amphiphilic secondary structures in neuopeptide Y through the design, synthesis and study model peptides" J. Biol. Chem 264, 7907-7913, May 1989.

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