Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-06
2006-06-06
Weber, Jon (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S194000, C530S358000
Reexamination Certificate
active
07056683
ABSTRACT:
The invention provides fusion protein reporter molecules that can be used to monitor protein modifications (e.g., histone modifications) in living cells, and methods of using the fusion reporter molecules for diagnosing protein-modification-associated disorders (e.g. histone-modification-associated disorders). The invention also provides methods of using the fusion protein reporters to identify candidate pharmaceutical agents that effect protein modification in cells and tissues, thus permitting identification of candidate pharmaceutical agents for treatment of protein-modification-associated disorders.
REFERENCES:
patent: 5503977 (1996-04-01), Johnsson et al.
patent: 5585245 (1996-12-01), Johnsson et al.
patent: 5625048 (1997-04-01), Tsien et al.
patent: 6124128 (2000-09-01), Tsien et al.
patent: 6465199 (2002-10-01), Craig et al.
patent: 2002/0019002 (2002-02-01), Griffiths
patent: 2002/0090643 (2002-07-01), Craig et al.
patent: 2002/0164674 (2002-11-01), Tsien et al.
patent: 2002/0165364 (2002-11-01), Tsien et al.
patent: 2003/0186229 (2003-10-01), Tsien et al.
patent: WO 96/23810 (1996-08-01), None
patent: WO 01/33199 (2001-05-01), None
patent: WO 02/066656 (2002-08-01), None
patent: WO 02/079391 (2002-10-01), None
patent: WO 02/095058 (2002-11-01), None
Reichheld et al., Multilevel regulation of histone gene expression during the cell cycle in tobacco cells. Nucleic Acids Res. Jul. 1, 1998;26(13):3255-62.
Akhtar et al., Chromodomains are protein-RNA interaction modules.Nature. Sep. 21, 2000;407(6802):405-9.
Agalioti, T. et al, Deciphering the transcriptional histone acetylation code for a human gene.Cell111: 381-392, 2002..
Ait-Si-Ali, S. et al., CBP/p300 histone acetyl-transferase activity is important for the G1/S transition.Oncogene19: 2430-2437, 2000.
Belyaev, N.D. et al., Histone H4 acetylation and replication timing in Chinese hampster chromosomes.Experimental Cell Research225: 277-285, 1996.
Campbell, R.E. et al., A monomeric red fluorescent protein.Proc. Natl. Acad. Sci. USA99(12): 7877-7882, 2002.
Chen, H. et al., Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of acetylase.Cell98: 675-686, 1999.
Cheung, P. et al., Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.Molecular Cell5: 905-915, 2000.
Dhalluin, C. et al., Structure and ligand of a histone acetyltransferase bromodomain.Nature399: 491-496, 1999.
Fischle, W. et al., Histone and chromatin cross-talk.Current Opinion in Cell Biology15: 172-183, 2003.
Fu, H. et al., 14-3-3 proteins: structure, function and regulation.Annual Review Pharmacology and Taxicology40: 617-647, 2000.
Goto, H. et al, Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.Journal of Biological Chemistry274: 25543-25549, 1999.
Jacobson, R.H. et al., Structure and function of a human TAF11250 double bromodomain module.Science288: 1422-1425, 2000.
Kimura, H. et al., Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B.The Journal of Cell Bioloy153(7): 1341-1353, 2001.
Lachner, M. et al., The many faces of histone lysine methylation.Current Opinion in Cell Biology14: 286-298, 2002.
Marmorstein, R., Protein modules that manipulate histone tails for chromatin regulation.Nat. Rev. Mol. Cell Biol., 2: 422-432, 2001.
New, L. et al., Cloning and characterization of RLPK, a novel RSK-related protein kinase.Journal of Biological Chemistry274 (2): 1026-1032, 1999.
Nielsen, P.R. et al., Structure of the HPI chromodomain bound to histone H3 methylated at lysine 9.Nature416: 103-107, 2002.
Perissi, V. et al., Factor-specific modulation of CREB-binding protein acetyltransferase activity.Proc. Natl. Acad. Sci. USA96: 3652-3657, 1999.
Rea, S. et al., Regulation of chromatin structure by site-specific histone H3 methyltransferases.Nature406: 593-599, 2000.
Shankaranarayanan, P. et al., Acetylation by histone acteyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene.The Journal of Biological Chemistry276(46): 42753-42760, 2001.
Tachibana, M. et al., G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.Genes and Development16: 1779-1791, 2002.
Taddei, A. et al., Duplication and maintenance of heterochromatin domains.The Journal of Cell Biology147: 1153-1166, 1999.
Ting, A.Y. et al., A Fluorescent probe of tyrosine phosphorylation in vivo, Grant No. IF32GM063443-01, University of California San Diego, Grant Year 2001, NIH CRISP database at http://crisp.cit.nig.gov/..
Ting, A.Y. et al., Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells.PNAS98(26): 15003-15008, 2001.
Yaffe, M.B. et al., A motif-based profile scanning appoach for genome—wide prediction of signalling pathways.Nature Biotechnology19: 348-353, 2001.
Yaffe, M.B. et al., The structural basis for 14-3-3: phosphopeptide biding specificity.Cell91: 961-971, 1997.
Zacharias, D.A. et al., Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.Science, 296: 913-916, 2002.
Zhang, J. et al., Creating new fluoresent probes for cell biology.Nat. Rev. Mol. Cell. Biol., 3: 906-18, 2002.
Zhang, Y. et al., Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.Genes and Development, 15: 2343-2360, 2001.
Zhong, S. et al., Ultraviolet B-induced phosphorylation of histone H3 at serine 28is mediated by MSK1.J. Biol. Chem. 276(35), 33213-33219, 2001.
Feroli et al., Analysis of a 17-9 kb region fromSaccharomyces cerevisiaechromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes. Yeast. 13(4):373-377, 1997.
Marcus et al., Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J. 13(20):4807-4815, 1994.
Mazzoni et al., Sequence analysis of a 10-5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThrgene. Yeast. 13(4):369-372, 1997.
Adams, S. et al, “Fluorescence ratio imaging of cyclic AMP in single cells,”Nature349: 694-697, 1991.
Aitken, A. et al, “14-3-3 proteins: biological function and domain structure,”Biochemical Society Transactions, 605-611, Received Mar. 3, 1995.
Baldwin, T. et al, “Cloning and Expression of theluxY Gene fromVibrio fischeriStrain Y-1 inEscherichia coliand Complete Amino Acid Sequence of the Yellow Fluorescent Protein,”Biochemistry29: 5509-5515, 1990.
Cervoni, N. et al, “Demethylase Activity Is Directed by Histone Acetylation*,”Journal of Biological Chemistry276(44): 40778-70787, 2001.
Chen, I. et al, “Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase,”Nature Methods2(2): 99-104, 2005.
Cubitt, A. et al, “Understanding, improving and using green fluorescent proteins,”Techniques TIBS20: 448-455, 1995.
González, J. et al, “Volatge Sensing by Fluorescence Resonance Energy Transfer in Single Cells,”Biophysical Journal69: 1272-1280, 1995.
Heim, R. et al, “Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy trasnfer,”Current Biology6: 178-182, 1996.
Heim, R. et al, “Wavelength mutations and posttranslational autoxidation of green fluorescent protein,”Proc. Natl. Acad. Sci. USA91: 12501-12504, 1994.
Herman, B. “Resonance Transfer Microscopy,”Methods in Cell Biology, Chapter 8vol. 30: 219-243, 1989.
Huston, J. et al, “Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced inEscherichia coli,” Proc. Natl. Acad. Sci. USA85: 5879-5883, 1988.
Levine, L. et al, “Isolation and Character
Massachusetts Institute of Technology
Mondesi Robert B.
Weber Jon
Wolf Greenfield & Sacks P.C.
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