Genetically encoded fluorescent coumarin amino acids

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S325000

Reexamination Certificate

active

07807411

ABSTRACT:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such asE. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.

REFERENCES:
patent: 5998593 (1999-12-01), Huff et al.
patent: 6927042 (2005-08-01), Schultz et al.
patent: 7045337 (2006-05-01), Schultz et al.
patent: 7083970 (2006-08-01), Schultz et al.
patent: 7129333 (2006-10-01), Schultz et al.
patent: 7183082 (2007-02-01), Schultz et al.
patent: 7199222 (2007-04-01), Schultz et al.
patent: 7217809 (2007-05-01), Schultz et al.
patent: 7238510 (2007-07-01), Schultz et al.
patent: 7262040 (2007-08-01), Schultz et al.
patent: 2003/0108885 (2003-06-01), Schultz et al.
patent: 2004/0198637 (2004-10-01), Schultz et al.
patent: 2004/0265952 (2004-12-01), Deiters et al.
patent: 2005/0009049 (2005-01-01), Chin et al.
patent: 2005/0136513 (2005-06-01), Zhang et al.
patent: 2005/0208536 (2005-09-01), Schultz et al.
patent: 2005/0227318 (2005-10-01), Alfonta et al.
patent: 2005/0272121 (2005-12-01), Xie et al.
patent: 2006/0063244 (2006-03-01), Schultz et al.
patent: 2006/0068478 (2006-03-01), Schultz et al.
patent: 2006/0073507 (2006-04-01), Deiters et al.
patent: 2006/0110784 (2006-05-01), Deiters et al.
patent: 2006/0110796 (2006-05-01), Schultz et al.
patent: 2006/0134746 (2006-06-01), Deiters et al.
patent: 2006/0160175 (2006-07-01), Anderson et al.
patent: 2006/0177900 (2006-08-01), Anderson et al.
patent: 2006/0234367 (2006-10-01), Schultz et al.
patent: 2006/0246509 (2006-11-01), Deiters et al.
patent: 2007/0009990 (2007-01-01), Alfonta et al.
patent: 2007/0020634 (2007-01-01), Anderson et al.
patent: 2007/0042461 (2007-02-01), Anderson et al.
patent: 2007/0111193 (2007-05-01), Zhang et al.
patent: 2007/0154952 (2007-07-01), Chin et al.
patent: 2007/0166791 (2007-07-01), Chin et al.
patent: 2007/0172915 (2007-07-01), Schultz et al.
patent: 2007/0178448 (2007-08-01), Tsao et al.
patent: 2007/0184517 (2007-08-01), Schultz et al.
patent: 2007/0238152 (2007-10-01), Wang et al.
patent: WO 2006/110182 (2006-12-01), None
patent: WO 2007/103490 (2007-09-01), None
Furter Protein Science, Expansion of the genetic code: Site directed p-fluoro-phenylalanine incorporation inEscherichia coli. vol. 7, pp. 419-426, 1998.
Pasternak et al. (A new orthogonal suppressor tRNA/Aminoacyl-tRNA synthetase pair for evolving an organism with an expanded genetic code Helvetica Chimica Acta vol. 83. pp. 227-2286, Sep. 25, 2000.
Wang et al (Addition of the keto functional group to the genetic code ofEscherichia coliPNAS Jan. 7, 2003, vol. 100, pp. 56-61.
Wang et al. Wang et al. (Expanding the Genetic ode ofEscherichia coli. Science Apr. 20, 2001, vol. 292, 498-500.
Chin et al. (An Expanded Eukaryotic Genetic Code, Science vol. 30, No. 5635 pp. 964-967 2003.
Brun et al. (2004) “A Very Short Route to Enantiomerically Pure Coumarin-Bearing Fluorescent Amino Acids.”Angew. Chem., Int. Ed., (2004) 43(26): 3432-3436.
Feng et al. (2003) “Expanding tRNA recognition of a tRNA synthetase by a single amino acid change”Proceedings of the National Academy of Sciences, USA, 100(10): 5676-5681.
Forster et al.,(2003) “Programming peptidomimetic synthetases by translating genetic codes designed de novo.”Proceedings of the National Academy of Sciences, USA, 100(11): 6353-6357.
Hohsaka et al. (2004) “Position-specific incorporation of dansylated non-natural amino acids into streptavidin by using a four-base codon.”FEBS Letters, 560: 173-177.
Mendel et al. (1995) “Site-directed Mutagenesis with an Expanded Genetic Code.”Annual Review of Biophysics&Biomolecular Structure, 24: 435-462.
Wang and Schultz (2005) “Expanding the Genetic Code,”Angewandte Chemie Int. Ed., 44(1): 34-66.
Wang and Schultz (2002) “Expanding the Genetic Code,”Chem. Commun., 1: 1-11.
Wang et al. (2006) “Expanding the Genetic Code,”Annual Review of Biophysics&Biomolecular Structure, 35: 225-249.
Xie and Schultz (2006) “A chemical toolkit for proteins—an expanded genetic code,”Nature Reviews: Molecular Cell Biology, 7(10): 775-782.
Xie and Schultz (2005) “Adding Amino Acids to the Genetic Repertoire.”Current Opinion in Chemical Biology, 9(6): 548-554.
Xie and Schultz (2005) “An Expanding Genetic Code,”Methods, 36(3): 227-238.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genetically encoded fluorescent coumarin amino acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetically encoded fluorescent coumarin amino acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetically encoded fluorescent coumarin amino acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4173703

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.