Genetically attenuated bacterial vaccines with multiple mutation

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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435172, 435851, 424 92, C12N 120

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active

043373143

ABSTRACT:
A vaccine composition comprising a genetically attenuated bacterial strain which contains at least two mutations of the same phenotype which strain is rendered avirulent while retaining immunogenicity.

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Metzler, Biochemistry, The Chemical Reactions of Living Cells, Academic Press, Inc., pp. 945 & 946 (1977).

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