Genetically attenuated bacterial vaccines with multiple mutation

Details Genetically attenuated bacterial vaccines with multiple mutation Genetically attenuated bacterial vaccines with multiple mutation

1984-02-16

1987-07-21

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 93, 4351721, 4351723, 435253, A61K 39102, A61K 3902, C12N 1500, C12N 120

Patent

active

046817620

ABSTRACT:
The present invention relates to a vaccine composition for the prevention of infectious diseases comprising an immunogenically-effective amount of a genetically attenuated and stable avirulent bacterial strain derived from a virulent bacterial strain by introducing into said virulent strain by genetic transfer and recombination at least two mutations of the same phenotype which renders said virulent strain avirulent, while permitting said avirulent strain to retain immunogenicity, together with an inert pharmacologically acceptable carrier. It also relates to a method for preparing the vaccine.

REFERENCES:
patent: 3856935 (1972-12-01), Germanier
patent: 4169886 (1979-10-01), Hertman et al.
patent: 4264737 (1981-04-01), Murphy
patent: 4328209 (1982-05-01), Finkelstein et al.

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