Genetic vaccines for the production of chicken egg-yolk...

Details Genetic vaccines for the production of chicken egg-yolk... Genetic vaccines for the production of chicken egg-yolk...

2008-04-08

2008-04-08

Wilson, Michael C. (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal to manufacture...

C800S019000, C800S021000

Reexamination Certificate

active

10169027

ABSTRACT:
Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenicEscherichia coli(ETEC) strains is disclosed. Additionally, plasmids may consist of multiple copies of the same antigen (i.e. K88 or K99 fimbrial antigen) or multiple antigens (ie. K88 and K99 fimbrial antigens) and genetic adjuvants such as cytokines (IL-2, IL-4 & GM-CSF), costimulatory molecules (CD80 & CD86) or chemokines or immunostimulatory sequences. A method for isolating antibodies from chicken egg yolk for passive immunization of animals, as well as humans to control diarrhoeal diseases using the genetic vaccines is also disclosed.

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