Genetic test for equine severe combined immunodeficiency disease

Details Genetic test for equine severe combined immunodeficiency disease Genetic test for equine severe combined immunodeficiency disease

1997-11-14

1999-11-02

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435194, 530350, 536 232, 536 235, C12Q 168, C12P 1934, C07H 2104

Patent

active

059768037

ABSTRACT:
The present invention relates to the discovery of the mutation of a DNA-dependent protein kinase protein which results in equine severe combined immunodeficiency (SCID). Specifically, the present invention provides the sequence of the normal and SCID DNA-dependent protein kinase genes, proteins, and provides diagnostic tests for identifying carriers of the mutation utilizing oligonucleotides that differentiate between the normal and the SCID alleles.

REFERENCES:
patent: 5476996 (1995-12-01), Wilson et al.
Wiler et al., Proc. Natl. Acad. Sci. USA 92, 11485-11489 (1995).
Wiler et al., Vet. Immunol. Immunopath. 54, 19 (1996).
Shin et al., J. Immunol. 158(8), 3565-3569 (1997).
Shin et al., J. Am. Vet. Med. Assoc. 211(10), 1268-1270 (1997).

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