Genetic polymorphisms associated with venous thrombosis,...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

08071291

ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

REFERENCES:
patent: 2007/0269827 (2007-11-01), Harley
patent: 2005056837 (2005-06-01), None
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Arellano, A., et al., “Gene Variants Associated with Venous Thrombosis: Confirmation in the MEGA Study,” Journal of Thrombosis and Haemostasis, Jan. 25, 2010, Letter to the Editor.
Bezemer, I., et al., “Gene Variants Associated with Deep Vein Thrombosis,” Journal of the American Medical Association, Mar. 19, 2008, vol. 299, No. 11, pp. 1306-1314 and Supplementary Online eTable Entitled, “48 SNPs in CYP4V2 Region Genotyped in the Leiden Thrombophilia Study”.
Li, Y., et al., “Gene Variants Associated with Deep Vein Thrombosis: the F11 Locus,” Journal of Thrombosis and Haemostasis, 2009, vol. 7, pp. 1802-1808.
Reiner, A., et al., “Common Hemostasis and Inflammation Gene Variants and Venous Thrombosis in Older Adults from the Cardiovascular Health Study,” Journal of Thrombosis and Haemostasis, 2009, vol. 7, pp. 1499-1505.
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International Preliminary Report on Patentability, issued for PCT/US09/37069, dated Sep. 23, 2010.
Dilley, A., et al., “Relation of Three Genetic Traits to Venous Thrombosis in an African-American Population,” American Journal of Epidemiology, 1998, vol. 147, No. 1, pp. 30-35.
Pan, M., et al., “Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism is Associated with Left Ventricular Hypertrophy but not Essential Hypertension,” Hypertension Research, 2007, vol. 30, pp. 31-37.
International Search Report and Written Opinion, issued for PCT/US09/37069, dated Apr. 9, 2010.

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