Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-03-22
2011-03-22
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200
Reexamination Certificate
active
07910303
ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular VT and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
REFERENCES:
patent: 2005/0026169 (2005-02-01), Cargill et al.
patent: WO 00/58519 (2000-10-01), None
Bezemer, I. D., et al., “Gene Variants Associated with Deep Vein Thrombosis,” Journal Of The American Medical Association, Mar. 19, 2008, vol. 299, No. 11, pp. 1306-1314.
Bezemer, I. D., et al., “F9 Malmo, Factor IX and Deep Vein Thrombosis,” Haematologica, Mar. 13, 2009, vol. 94, No. 5, pp. 693-699.
Lowe, Gordon, “Factor IX and Deep Vein Thrombosis,” Haematologica, Mar. 13, 2009, vol. 94, No. 5, pp. 615-617.
Lijfering, W. M., et al., “A Replication Study of Gene Variants Associated with Venous Thrombosis. Results from a Population-Based Nested Case-Cohort Study,” Pathophysiology Of Thrombosis, Dec. 7, 2009, pp. 1-2.
International Search Report and Written Opinion dated Aug. 21, 2008.
International Preliminary Report On Patentability, dated Apr. 30, 2009.
Bare Lance
Bezemer Irene D.
Devlin James J.
Reitsma Pieter H.
Rosendaal Frits R.
Celera Corporation
Lieden University Medical Center (LUMC)
Switzer Juliet C
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