Genetic polymorphisms associated with rheumatoid arthritis,...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023100, C536S024330, C536S024300

Reexamination Certificate

active

07833706

ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

REFERENCES:
patent: WO 99/36548 (1999-07-01), None
patent: WO 01/11084 (2001-02-01), None
patent: WO 02/074989 (2002-09-01), None
Ittah M et al ‘No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjogren's syndrome.’ Arthritis Res Ther. 2006;8(1):457-458.
Vandiedonck C et al 'Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. Ann Neurol. Feb. 2006;59(2):404-7.
Hacker UT et al ‘Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis.’ Gut. May 1997;40(5):623-7.
GenBank GI:14970654 ‘Human DNA sequence from clone RP5-1073O3 on chromosome 1p13.1-13.3, complete sequence’ 2001, pp. 1-51.
Criswell LA et al ‘Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.’ Am J Hum Genet. Apr. 2005;76(4):561-71.
Begovich AB et al ‘A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.’ Am J Hum Genet. Aug. 2004;75(2):330-7.
Lee AT et al ‘The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.’ Genes Immun. Mar. 2005;6(2):129-33.
Harrison P et al ‘Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.’ Rheumatology (Oxford). Aug. 2006;45(8):1009-11.
Database Genbank Retrieved on Dec. 7, 2004 Jul. 6, 2000, “Human DNA Sequence from Clone RP11-179A5 on Chromosome 1” Database Accession No. AL365225.
Morgan, Ann W. et al., “Fcgamma Receptor Type IIIA is associated with Rheumatoid Arthritis in Two Distinct Ethnic Groups”, Arthritis and Rheumatism, vol. 43, No. 10, Oct. 2000, pp. 2328-2334.
Waldon-Lynch F. et al., “Tumour Necrosis Factor 5′ Promoter Single Nucleotide Polymorphisms Influence Susceptibility to Reheumatoid Arthritis (RA) in Immunogenetically Defined Multiplex RA Families”, Genes and Immunity, Apr. 2001, pp. 82-87.
Yamada, R. et al., “Association between a Single-Nucleotide Polymorphism in the Promoter of the Human Interleukin-3 Gene and Rheumatoid Arthritis in Japanese Patients and Maximum-Likelihood Estimation of . . . Effect that Two Genetic Loci Have on Susceptibility to the Diseases”, American Journal of Human Genetics, American Society of Human Genetics, Chicago, IL, U.S., vol. 68, No. 3, 2001, pp. 674-685.
International Search Report dated Oct. 19, 2004.
Written Opinion dated Oct. 19, 2004.
Van Oene, Mark, et al., “Association of the Lymphoid Tyrosine Phosphatase R620W variant with Rheumatoid Arthritis, but not Crohn's Disease, in Canadian Populations,” Arthritis and Rheumatism, vol. 52, No. 7, Jul. 2005, pp. 193-198.
Siminovitch, K. A.,“PTPN 22 and Autoimmune Disease,” Nature Genetics, vol. 36, No. 12, Dec. 2004, pp. 1248-1249.
Database DBSNP [Online] National Institutes of Health, USA; Assay for Reference SNP Id rs2476601, Sep. 24, 2001, “Submitted SNP Report ss3470759”, XP002457273 retrieved from NCBI Database Acession No. ss3470759.
European Search Report, Nov. 29, 2007, pp. 1-5.

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