Genetic polymorphisms associated with rheumatoid arthritis,...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C536S023100, C536S024330

Reexamination Certificate

active

07811794

ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with rheumatoid arthritis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

REFERENCES:
Hacker UT et al ‘Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis.’ Gut. May 1997;40(5):623-7.
GenBank GI:16874864 ‘Homo sapienschromosome 3 clone RP11-78O10, Working Draft Sequence, 8 unordered pieces’ 2001, pp. 1-48.
Criswell LA et al ‘Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.’ Am J Hum Genet. Apr. 2005;76(4):561-71.
Begovich AB et al ‘A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.’ Am J Hum Genet. Aug. 2004;75(2):330-7.
Lee AT et al ‘The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.’ Genes Immun. Mar. 2005;6(2):129-33.
Harrison P et al ‘Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.’ Rheumatology (Oxford). Aug. 2006;45(8):1009-11.
Chen JY et al ‘Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis.’ Clin Exp Immunol. Apr. 2006;144(1):10-16.
‘Date Changes that Occur Between Builds’ from the SNP FAQ Archive, acessed online on Oct. 28, 2008 at: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=helpsnpfaq.section.Build.Data—Changes—that—Oc printed pp. 1-3 provided.
DataBase EMBL Online ! Jun. 9, 1995, “Homo sapiens(clones HGPCD2 and HGPCD15) pterin-4a-carbinolamine dehydrates (PCBD) gene, complete cds.” XP002310444 retrieved from EBI accession No. EM—HUM: L41560; Database accession No. L41560.
Thony Beat et al.; “Characterization of the Human PCBD Gene Encoding the Bifunctional Protein Pterin-4-Alpha-Carbinolamine Dehydratase/Dimerization of cofactor for the Transcription Factor HNF-1-Alphe” Biochemical and Biophysical Research Communications, vol. 210, No. 3, 1995, pp. 966-973, ISSN: 0006-291X.
DataBase EMBL ′Online!; Apr. 9, 2000, “Homo sapienschromosome 10 clone RP11-29P24 map 10, Working Draft Sequence, 17 unordered pieces.” XP002310248 retrieved from EBI accession No. EM—HTG: AC023639.
DataBase EMBL ′Online!; Jun. 8, 2000, “Homo sapienschromosome 10 clone RP11-205C5, complete sequence.” XP002310249 retrieved from EBI accession No. EM—HUM: AC069538.
DataBase EMBL ′Online!; Sep. 6, 2001, “603189135F1 NIH—MGC—95Homo sapienscDNA clone iMAGE: 5260425 5′, mRNA sequence.” XP002310466 retrieved from EBI accession No. EM—EST: BI548743; Database accession No. BI548743.
WO 01/11084 A (Kimberly Robert P; UAB Research Foundation (US); Gibson Andrew (US) Feb. 15, 2001 p. 8, line 5—p. 14, line 17 claims 7,8.
WO 02/074989 A (Gough Stephen; Todd John (GB); Ueda Hironori (GB); Catalyst Biomedica Sep. 26, 2002 p. 42, line 22—p. 45, line 5; claims 1-4.
Morgan Ann W et al.; “Fogamma Receptor Type IIIA is Associated with Rheumatoid Arthritis in Two Distinct Ethnic Groups” Arthritis and Rheumatism, vol. 43, No. 10, Oct. 2000, pp. 2328-2334, XP002288078; ISSN: 0004-3591.
Waldron-Lynch F et al.; Tumor Necrosis Factor 5′ Promoter Single Nucleotide Polymorphisms influence Susceptibility to Rheumatoid Arthritis (RA) in Immunogenetically defined multiplex RA Families; Genes and Immunity; Apr. 2001, vol. 2, No. 2, Apr. 2001, pp. 82-87, XP009082935; ISSN: 14664879.
Yamada R et al.; “Association between a single-nucleotide polymorphisms in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients and maximum-likelihood estimation of . . . Effect that two genetic loci have susceptibility to the disease”; American Journal of Human Genetics, American Society of Human Genetics, Chicago, IL, US, vol. 68, No. 3, 2001, pp. 674-685, XP002972306; ISSN: 0002-9297.
Thony B, et al.; “Hyperphenylalaninemia with High Levels of 7-Bioptern is associated with Mutations in the PCBD Gene Encoding the Bifunctional Protein Pterin-4A-Carbinolamine Dehydratase and Transcriptional Coactivator (DC0H).”; American Journal of Human Genetics; Jun. 1998, vol. 62, No. 6, Jun. 1998, pp. 1302-1311, XP002310443; ISSN: 0002-9297.
International Search Report and Written Opinion dated Mar. 2, 2005.
Van Oene, Mark, et al., “Association of the Lymphoid Tyrosine Phosphatase R620W Variant with Rheumatoid Arthritis, but not Crohn's Disease, inCanadian Populations,” Arthritis and Rheumatism, vol. 52, No. 7, Jul. 2005, pp. 1993-1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genetic polymorphisms associated with rheumatoid arthritis,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetic polymorphisms associated with rheumatoid arthritis,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic polymorphisms associated with rheumatoid arthritis,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4180799

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.