Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2011-01-04
2011-01-04
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C536S023100, C536S024330
Reexamination Certificate
active
07863021
ABSTRACT:
The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoimmune disease, particularly rheumatoid arthritis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
REFERENCES:
patent: 6673908 (2004-01-01), Stanton et al.
patent: 2007/0031846 (2007-02-01), Cargill et al.
patent: 01/57182 (2001-08-01), None
Chang, M., et al., “A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2,” PLOS Genetics, Jun. 2008, vol. 4, Issue 6, e1000107, 17 pgs.
Han, T., et al., “TRAF1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Asians and in Caucasians,” Arthritis & Rheumatism, Jun. 2009, vol. 60, No. 9, pp. 2577-2584.
International Preliminary Report on Patentability, issued for PCT/US2008/100439, dated Mar. 18, 2010.
NCBI refSNP ID: rs2109895. May 2, 2006 [online], [retrieved on Mar. 24, 2009 from the internet <URL:http//www.ncbi.nlm.nih.gov/SNP/snp—ref.cgi?rs=2109895>; p. 1-ref SNPID; also see 3′ and 5′ flanking sequences on p. 1 submitter records.
NCBI refSNP ID: rs2239657. May 2, 2006 [online], [retrieved on Mar. 24, 2009 from the internet <URL:http//www.ncbi.nlm.nih.gov/SNP/snp—ref.cgi?rs=2239657>; p. 1-ref SNPID; also see 3′ and 5′ flanking sequences on p. 1 submitter records, RefSNP Alleles.
NCBI refSNP ID: rs7021880. May 2, 2006 [online], [retrieved on Mar. 24, 2009 from the internet <URL:http//www.ncbi.nlm.nih.gov/SNP/snp—ref.cgi?rs=7021880>; p. 1-ref SNIPID; also see 3′ and 5′ flanking sequences on p. 1 submitter records, RefSNP Alleles.
NCBI refSNP ID: rs7021049. May 2, 2006 [online ], [retrieved on Mar. 24, 2009 from the internet <URL:http//www.ncbi.nlm.nih.gov/SNP/snp—ref.cgi?rs=7021049>; p. 1-ref SNPID; also see 3′ and 5′ flanking sequences on p. 1 submitter records, RefSNP Alleles.
International Search Report and Written Opinion, dated Apr. 28, 2009, 15 pages.
Bogovich Ann B.
Schrodi Steven J.
Bausch Sarae
Celera Corporation
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