Genetic polymorphisms associated with liver fibrosis methods...

Details Genetic polymorphisms associated with liver fibrosis methods... Genetic polymorphisms associated with liver fibrosis methods...

2010-09-20

2011-12-06

Goldberg, Jeanine A (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S006110, C435S091100, C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

08071302

ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

REFERENCES:
Romeo, S., et al. Nature Genetics (Sep. 25, 2008) doi:10.1038
g.257.
Valenti, L., et al. Hepatology (2011) 53:3:791-799.
Trepo, E. Hepatology (2011) 54:1:60-69.
Krawczyk et al., Journal of Hepatology (2011) doi:10.1016/j.jhep.2010.10.042.
Romeo, S., et al., “Genetic Variation in PNPLA3 Confers Susceptibility to Nonalcoholic Fatty Liver Disease,” Nature Genetics, vol. 40, 2008, pp. 1461-1465.
Stickel, F., et al., “Genetic Variation in the PNPLA3 Gene is Associated with Alcoholic Liver Injury in Caucasians,” Hepatology, vol. 53, No. 1, 2011, pp. 86-95.

Affiliated with

Also associated with

Rating

Genetic polymorphisms associated with liver fibrosis methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetic polymorphisms associated with liver fibrosis methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic polymorphisms associated with liver fibrosis methods... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4258748