Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-05-09
2010-10-26
Goldberg, Jeanine A (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
07820380
ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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Bahr, M. J., et al., “Cytokine Gene Polymorphisms and the Susceptibility to Liver Cirrhosis in Patients with Chronic Hepatitis C,” Liver International, vol. 23, Dec. 2003, pp. 420-425.
Bataller, R., et al., “Genetic Polymorphisms and the Progression of Liver Fibrosis: a Critical Appraisal,” Hepatology, vol. 37 No. 3, Mar. 2003, pp. 493-503.
Hamada, H., et al., “Interlukin-10 Promoter Polymorphisms and Liver Fibrosis Progression in Patients with Chronic Hepatitis C in Japan,” Journal of Hepatology, vol. 39 No. 3, Sep. 2003, pp. 457-458.
Smirnova, I., et al., “Excess of Rare Amino Acid Polymorphisms in the Toll-Like Receptor 4 in Humans,” Genetics, vol. 158, Aug. 2001, pp. 1657-1664.
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Celera Corporation
Goldberg Jeanine A
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