Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-26
2010-06-01
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200
Reexamination Certificate
active
07727725
ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
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patent: 2005/111241 (2005-11-01), None
NCBI Single Nucleotide Polymorphism database, submitted SNP(ss) Details for ss95212010, including method description, accessed from http://www.ncbi.nlm.nih.gov/SNP on Jan. 6, 2010, four pages.
Hirschhorn, Joel, N. et al., A Comprehensive Review of Genetic Association Studies, Genetics in Medicine, Mar./Apr. 2002, pp. 45-61, vol. 4, No. 2.
Reference SNP(refSNP) Cluster Report: rs886277, http//www.ncbi.nlm.nih.gov/SNP/snp—ref.cgi?db=human—9606&na=1&gnl=gnl%7CdbSNP%7Crs886277&RID=6HV6ET610, dbSNP build 86, Oct. 16, 2000.
Invitation to Pay Additional Fees and, Where Applicable, Protect Fees, dated Jul. 16, 2008.
International Search Report and Written Opinion of the International Searching Authority, dated Sep. 12, 2008.
Christensen, G. L., et al., “Identification of Polymorphisms and Balancing Selection in the Male Infertility Candidate Gene, Ornithine Decarboxylase Antizyme 3”, BMC Medical Genetics, 2006, 7:27.
Koguchi, K., et al., “Cloning and Sequencing of a Human cDNA Encoding Ornithine Decarboxylase Antizyme Inhibitor”, Biochimica et Biophysica Acta, 1997, vol. 1353, pp. 209-216.
Cargill Michele
Huang Hongjin
Venkatesh Ramasubbu
Celera Corporation
Switzer Juliet C
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