Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-03-10
2009-12-01
Goldberg, Jeanine A (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
07625699
ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
REFERENCES:
patent: 6368594 (2002-04-01), Doetsch et al.
patent: 2003/0092019 (2003-05-01), Meyer et al.
patent: WO 94/23638 (1994-10-01), None
patent: WO 99/57315 (1999-11-01), None
patent: WO 00/71753 (2000-11-01), None
patent: WO 03/007801 (2003-01-01), None
patent: WO 2004/058990 (2004-07-01), None
Avakian et al. (Clinical Genetics, vol. 60, pp. 381-384, 2001).
Hirschhorn et al. (Genetics in Medicine. vol. 4, No. 2, pp. 45-61, Mar. 2002).
loannidis (Nature Genetics, vol. 29, pp. 306-309, Nov. 2001).
Genbank Accession No. rs3798220, Aug. 12, 2002.
Nollau et al. (Clinical Chemistry, vol. 43, No. 7, pp. 1114-1128, 1997).
Willeit, J. et al., “Marburg I Polymorphism of Factor VII-Activating Protease A Prominent Risk Predictor of Cartoid Stenosis”, Circluation, American Heart Association, Dallas, TX, US, vol. 187, No. 5, Feb. 2003, pp. 667-670.
Avakian S. et al., “Apolipoproteins AI, B and E Polymorphisms in Severe Aortic Valve Stenosis”, Clinical Genetics, vol. 60, No. 5, Nov. 2001, pp. 381-384.
Olivieri, O. et al., “Genetic Polymorphisms of the Renin-Angiotensin System and Atheromatous Renal Artery Stenosis”, Hypertension, Baltimore, vol. 34, No. 5, Nov. 1999, pp. 1099-1100.
Kostulas, K. et al., “An Angiotensin-Converting Enzyme Gene Polymorphism Suggests a Genetic Distinction Between Ischaemic Stroke and Cartoid Stenosis”, European Journal of Clinical Investigation, vol. 29, No. 6, Jun. 1999, pp. 478-483.
Garcia-Ribes, M. et al., “Polymorphism of the Platelet Glycoprotein IIIa Gene in Patients with Coronary Stenosis”, Thrombosis and Haemostasis, vol. 79, No. 6, Jun. 1998, pp. 1126-1129.
Carter, A.M. et al., “Association of the Fibrinogen Alpha312A/G Polymorphism with Myocardial Infarction and Extent of Stenosis in Patients with Coronary Artery Disease Characterized by Coronary Angiography”, European Heart Journal, vol. 19, Aug. 1998, p. 39.
Missouris, C. G. et al., “Genetic Risk for Renal Artery Stenosis: Association with Deletion Polymorphism in Angiotensin 1-Converting Enzyme Gene”, Kidney International, vol. 49, No. 2, 1996, pp. 534-537.
McCormick, S. M. et al., “Microarray Analysis of Shear Stressed Endothelial Cells”, Biorheology, vol. 40, No. 1-3, 2002 pp. 5-11.
Eskin, S.G. et al., “Endothelial Cell Cytochrome P450 (CYP) 1A1 and 1B1: Upregulation by Shear Stress”, FASEB Journal, vol. 16, No. 4, Mar. 20, 2002, pp. A208-A209.
Kerzee, J. K. et al., “Constitutive and Inducible Expression of Cyp1a1 and Cyp1b1 in Vascular Smooth Muscle Cells: Role of the Ahr bHLH/PAS Transcription Factor”, Circulation Research, vol. 89, No. 7, Sep. 28, 2001, pp. 573-582.
Dubey, R. K. et al., “CYP450 and COMT-Derived Estradiol Metabolites Inhibit Activity of Human Coronary Artery SMC's”, Hypertension, vol. 41, No. 3 Part 2, Macrh 2003, pp. 807-813.
International Search Report dated Sep. 9, 2005.
Written Opinion dated Sep. 9, 2005.
Devlin James J.
Luke May M.
Celera Corporation
Goldberg Jeanine A
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