Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-07-12
2011-07-12
Goldberg, Jeanine A (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
07977052
ABSTRACT:
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
REFERENCES:
patent: 2003/0092019 (2003-05-01), Meyer et al.
patent: 1531180 (2005-05-01), None
patent: WO 2004/001037 (2003-12-01), None
patent: WO 2004/081186 (2004-09-01), None
patent: WO 2004/081187 (2004-09-01), None
Shiffman et al. (Arterioscler Thromb Vasc Biol, vol. 26, pp. 1613-1618. 2006).
Shiffman et al. (Arterioscler Thromb Vasc. Biol., vol. 28, 173-179, 2008).
NCBI rs 1010 (see ss1034, Jan. 1999).
Database SNP NCBI; XP002409007; http://www.ncbi.nlm.nih.gov/SNP/snp ref.cgi?rs=1051038.
Cheng, S. et al., “A Multilocus Genotyping Assay for Candidate Markers of Cardiovascular Disease Risk ”, Genome Research, vol. 9, 199, pp. 936-949.
Daley, G. Q., et al., “The Heart SNPs a Beat: Polymorphisms in Candidate Genes for Cardiovascular Disease”, Trends .In Cardiovascular Medicine, vol. 11, No. 2, 2001, pp. 60-66.
Podos, S. D. et al., “LDLC Encodes a Brefeldin A-Sensitive, Peripheral Golgi Protein Required for Normal Golgi Function”, The Journal of Cell Biology, vol. 127, No. 3, Nov. 1994, pp. 679-691.
Polgar, J. et al., “Vesicle-Associated Membrane Protein 3 (VAMP-3) and VAMP-8 Are Present in Human Platelets and are Required for Granule Secretion”, Blood, vol. 100, No. 3, Aug. 2002, pp. 1081-1083.
International Search Report dated Sep. 12, 2007.
Written Opinion dated Sep. 12, 2007.
Database Genebank [Online] XP002546163 retreived from NCBI, Database Accession No. dbSNP ss1540289, Database accession No. AA994106.
Shiffman, D., et al., “Identification of Novel Genetic Markers Associated with Risk of Myocardial Infarction from a Genomic Scale Scan of Putative Functional Polymorphisms”, Journal of the American College of Cardiology, Mar. 3, 2004, vol. 43, No. 5, Supplement A, p. 488A.
Shiffman, D., et al., “ROS1 and TAS2R50 are Associated with Myocardial Infarction: Novel Genetic Associations in Three Sample”, Circulation, Nov. 10, 2004, vol. 110, No. 17, Supplement S, p. 823.
Yamada, Y., et al., “Prediction of the Risk of Myocardial Infarction from Polymorphisms in Candidate Genes”, The New England Journal of Medicine, Dec. 12, 2002, vol. 347, No. 24, pp. 916-923.
Supplementary European Search Report issued for EP009010224, dated Oct. 2, 2009.
Devlin James J.
Luke May M.
Shiffman Dov
Celera Corporation
Goldberg Jeanine A
LandOfFree
Genetic polymorphisms associated with coronary heart... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genetic polymorphisms associated with coronary heart..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic polymorphisms associated with coronary heart... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2653795