Genetic modification of endothelial cells

Details Genetic modification of endothelial cells Genetic modification of endothelial cells

1995-06-07

1999-12-14

Degen, Nancy

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435375, A61K 4800, C12N 510

Patent

active

060013508

ABSTRACT:
Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endothelial cells are useful in improving the performance of vascular grafts and in delivering the encoded polypeptide or protein, such as an enzyme, a hormone, a receptor or a drug, to an individual.

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